Not Available

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$999,936.00
Award Year:
2010
Program:
SBIR
Phase:
Phase II
Contract:
N44CO201000130
Award Id:
94139
Agency Tracking Number:
N43CO0800024
Solicitation Year:
n/a
Solicitation Topic Code:
NCI
Solicitation Number:
n/a
Small Business Information
504 S. Rosa Road, MADISON, WI, 53719-
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
Y
Duns:
794516695
Principal Investigator:
PAULWEST
Business Contact:
(608) 204-0104
bdonley@stemina.com
Research Institute:
n/a
Abstract

Brain tumor stem cells (BTSCs) are a subset population within tumors that are widely believed to be  responsible for tumor recurrence, due to their ability to self-renew, differentiate, migrate, and initiate tumor  propagation. Given these unique features, the selective targeting of BTSCs with novel therapies may prevent  tumor recurrence.    Stemina will progress efforts to determine BTSC biomarkers of efficacy by assessment of additional BTSC  and glioblastoma multiforme (GBM) lines for in vitro studies as well as execution of in vivo studies in this  Phase II project. Specifically, Stemina proposes to increase the robustness of the Phase I in vitro studies by  expanding metabolomics analysis to additional BTSC lines derived from GBM, in collaboration with the Mayo  Clinic and the University of Wisconsin-Madison. Stemina will evaluate treatment efficacy in vivo using the  Mayo Clinic¿s expertise in orthotopic mouse models to create in vivo models for each of the BTSC lines used  in vitro. Metabolomics will be performed in plasma from these models to establish in vivo biomarkers of  efficacy which will be validated and compared to in vitro biomarkers. Stemina expects to identify common  biomarkers from in vitro and in vivo studies that can be translated to a commercial product.

* information listed above is at the time of submission.

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