Immunotoxicity Monitoring Method for Unknown Noxious Exposures (IMMUNE)

Award Information
Agency: Department of Defense
Branch: Air Force
Contract: FA8650-05-M-6603
Agency Tracking Number: F051-076-1534
Amount: $99,997.00
Phase: Phase I
Program: SBIR
Awards Year: 2005
Solicitation Year: 2005
Solicitation Topic Code: AF05-076
Solicitation Number: 2005.1
Small Business Information
PHYSICAL SCIENCES, INC.
20 New England Business Center, Andover, MA, 01810
DUNS: 073800062
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Mitchell Zakin
 Area Manager, Life Sciences
 (978) 689-0003
 zakin@psicorp.com
Business Contact
 B. Green
Title: President, PSI R&D Operations
Phone: (978) 689-0003
Email: green@psicorp.com
Research Institution
N/A
Abstract
In this proposal we describe the development of a technology (nanoCyl) that can assay multiple protein biomarkers in small sample volume physiological fluids. It offers the potential for a novel immune assessment tool that can be deployed in the field for the rapid assessment of exposure of troops to a wide range of toxic agents. Proof of concept for the technology will be provided through the measurement of cytokine/chemokine expression profiles that characterize the immune system response to respiratory tract pathogens, through collaboration with Dr. Wayne Ensign of the Naval Health Research Center. A model profiling system will be demonstrated that will assay TNF-alpha and IL-1beta with an analyte detection sensitivity of < 10 pg/ml and a coefficient of variation of < 20%. This detection sensitivity is consistent with the changes in TNF-alpha and IL-1beta levels secreted into sputum. A subsequent Phase II project would involve the development of a prototype system suitable for deployment in the field.

* information listed above is at the time of submission.

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