PURIFICATION OF MELANOMA 250 KD TUMOR-ASSOCIATED ANTIGEN

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
7162
Agency Tracking Number:
7162
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
3508 University Dr Suite #2, Durham, NC, 27707
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
GARY M STUHLMILLER PHD
(919) 968-0433
Business Contact:
() -
Research Institution:
n/a
Abstract
THE GOAL OF THIS PROJECT IS TO IMPROVE THE EXISTING PURIFICATION PROCEDURE, DEVELOPED BY PIEDMONT RESEARCH COMPANY, FOR THE 250 KD MELANOMA TUMOR-ASSOCIATED ANTIGEN (TAA) TO ALLOW PRODUCTION OF ADEQUATE QUANTITIES OF PURIFIEDTAA FOR CLINICAL EVALUATION. PURIFIED TAA MAY PROVE AN EFFICIENT AGENT FOR IMMUNOTHERAPY AND FOR SPECIFIC IN VITRO ACTIVATION OF PATIENT T CELLS FOR SUBSEQUENT THERAPY. BOTH THE PURIFICATION PROCEDURE AND THE TAA PRODUCT WILL HAVE COMMERCIAL APPLICATIONS. BASIC METHODOLOGICAL APPROACHES WILL INCLUDE EVALUATION OF ALTERNATIVE TAA SOLUBILIZATION PROCEDURES, USE OF IMMUNOADHERENCE CHROMATOGRAPHY, AND EVALUATION OF THE DESTRUCTIVE EFFECTS OFENDOGENOUS PROTEASE ACTIVITY.

* information listed above is at the time of submission.

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