Improved Sensitivity in a Rapid, Label-Free Immunoassay using Liquid Crystals

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43GM077811-01
Agency Tracking Number: GM077811
Amount: $453,621.00
Phase: Phase I
Program: SBIR
Awards Year: 2006
Solicitation Year: 2006
Solicitation Topic Code: N/A
Solicitation Number: PHS2006-2
Small Business Information
PLATYPUS TECHNOLOGIES, LLC, 5520 Nobel Drive, Suite 100, MADISON, WI, 53711
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (608) 237-1270
Business Contact
Phone: (608) 237-1272
Research Institution
DESCRIPTION (provided by applicant): Liquid crystals can be used to image proteins on surfaces. In previous studies, we have shown that a combination of affinity contact printing techniques with liquid crystal imaging can form the basis for a rapid, label free detection technology, useful in the detection of antibodies. In this Phase 1 proposal, we undertake to increase the sensitivity of this approach to extend its usefulness to detection of low concentration molecules of clinical relevance, such as biomarkers and cytokines. We propose approaches that will permit detection of molecules present in solution at the pg/ml concentration. The success of this project will permit the development of high sensitivity, high density micro arrays based on liquid crystals for rapid, label free detection of low concentration molecules.

* Information listed above is at the time of submission. *

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