LC-based Nitric Oxide Breath Monitor for Asthma Management

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$399,939.00
Award Year:
2009
Program:
SBIR
Phase:
Phase I
Contract:
1R43HL095167-01
Award Id:
93932
Agency Tracking Number:
HL095167
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
5520 Nobel Drive, Suite 100, MADISON, WI, 53711
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
118040364
Principal Investigator:
AVIJITSEN
(608) 237-1270
ASEN@PLATYPUSTECH.COM
Business Contact:
RENEEHERBER
() -
rherber@platypustech.com
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): The goal of this project is to develop a liquid crystal-based sensor that can detect and measure nitric oxide in exhaled breath. The sensor technology is based on a broadly applicable detection platform that exploits th e sensitivity of liquid crystals (LCs) to the nanoscopic changes in the structure of surfaces. Many attributes of this LC technology suggest that it offers exciting potential for clinical applications. It can be used to fabricate low cost, highly specific sensor elements that analyze chemicals in real time (response in ~ 10 seconds), are highly sensitive (can detect 1 ppb or less in vapor phase), provide a wide dynamic range (4 orders of magnitude), offer format flexibility, and are easily customized to det ect selected compounds. Because the technology does not require expensive or complex instrumentation, or highly skilled personnel to operate the equipment, it is ideally suited as a cost-effective and reliable approach for breath monitoring. The outcome of this Phase I proposal will be a sensor element that can detect and measure ppb levels of exhaled nitric oxide. The LC-based sensor elements are small (lt1cm in size) and will be integrated with electronics to analyze and report analyte concentrations. Our intended product will display a readout of the collected data to the user. Such a product will enable self- monitoring by asthmatics and play a key role in disease management. PUBLIC HEALTH RELEVANCE: The goal of this project is to develop a liquid crysta l-based sensor that can detect and measure nitric oxide in exhaled breath. The sensor technology is based on a broadly applicable detection platform that exploits the sensitivity of liquid crystals (LCs) to the nanoscopic changes in the structure of surfac es. Many attributes of this LC technology suggest that it offers exciting potential for clinical applications. It can be used to fabricate low cost, highly specific sensor elements that analyze chemicals in real time (response in ~ 10 seconds), are highly sensitive (can detect 1 ppb or less in vapor phase), provide a wide dynamic range (4 orders of magnitude), offer format flexibility, and are easily customized to detect selected compounds. Because the technology does not require expensive or complex instru mentation, or highly skilled personnel to operate the equipment, it is ideally suited as a cost-effective and reliable approach for breath monitoring. The outcome of this Phase I proposal will be a sensor element that can detect and measure ppb levels of e xhaled nitric oxide. The LC-based sensor elements are small (lt1cm in size) and will be integrated with electronics to analyze and report analyte concentrations. Our intended product will display a readout of the collected data to the user. Such a product will enable self- monitoring by asthmatics and play a key role in disease management.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government