In-vivo Confocal Spectropolarimetric Imaging

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43CA124035-01A2
Agency Tracking Number: CA124035
Amount: $168,778.00
Phase: Phase I
Program: SBIR
Awards Year: 2007
Solicitation Year: 2007
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
DUNS: 129074840
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 (256) 562-0087
Business Contact
Phone: (256) 562-0087
Research Institution
DESCRIPTION (provided by applicant): The objective of the research proposed here is to develop and apply an in-vivo spectral optical imaging technique called confocal polarimetric imaging for the diagnosis of human skin lesions. The broader objectives include correlating the pathology of skin lesions to the acquired imagery and ultimately improving clinicians' diagnostic capabilities for skin lesions and their margins. The research is aimed at improving the diagnosis specificity of benign versus. (pre)malignant lesions and improving classification capabilities to preclude unwarranted invasive procedures such as biopsy and excision. Specific aims of the research include the design, construction, calibration, testing, and validation of a multimodality imager, coupled with a limited preliminary clinical trial to assess the technique's merit. It is expected that the high contrast imaging capabilities of confocal microscopy coupled with the morphologically sensitive technique of spectropolarimetric imaging will yield a more informative data cube that may be exploited for lesion discrimination purposes. In conjunction with a dermatologist and dermatopathologist, the device will be used to image skin lesions and the results correlated to clinical diagnoses and dermatopathology findings to assess its usefulness. The approach is expected to concurrently exploit the known advantages of the component imaging techniques to yield more informative architectural information about skin lesions, permitting improved in-vivo diagnostic capabilities vis- -vis traditional imaging approaches.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government