New Automated Protein Crystallization Apparatus

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$98,004.00
Award Year:
1995
Program:
SBIR
Phase:
Phase I
Contract:
1 R43 GM53342-01,
Award Id:
29464
Agency Tracking Number:
29464
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
220 Reservoir Street, Suite 28, Needham Heights, MA, 02194
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Douglas Collins
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
Advances in the modern understanding and control of biological systems have been richly informed bystructure information at the scale of interatomic distances. In human health, the impact of moleculaorganismic dysfunction, e.g., genetic, metabolic, hematologic, and other disease, is strongly dependmolecular structure. Diffraction studies of single crystals are the most reliable path to authoritatThe ultimate aim of this work is to make commercial off-the-shelf (COTS) instrumentation for automatsingle crystals available to every modern molecular biology and biochemistry laboratory. Other kindsmacromolecules will be considered at second priority. The crystals produced will be for crystal struX-ray diffraction and quasi-Laue neutron diffraction experiments. The apparatus will provide for prodynamic thermal control of supersaturation. In its multichamber design, one part will be for discoveconditions, and the other for crystal growth under programmed temperature control. Phase I: the appademonstrated to show merit and feasibility; Phase II: apparatus will be redesigned as necessary andprototype; Phase III: preceding work will be converted to COTS instrumentation.

* information listed above is at the time of submission.

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