Cell Density Monitor in Disposable Bag MoAb Bioreactors

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$86,570.00
Award Year:
2004
Program:
SBIR
Phase:
Phase I
Contract:
1R43CA108223-01
Award Id:
70683
Agency Tracking Number:
CA108223
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
POLESTAR TECHNOLOGIES, INC., 220 RESERVOIR ST, STE 32, NEEDHAM HEIGHTS, MA, 02494
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
RONALD MICHEELS
(781) 449-2284
RON@POLESTARTECH.COM
Business Contact:
KAREN CARPENTER
(781) 449-2284
KCARPENTER@POLESTARTECH.COM
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): There is a need for an in-situ cell density monitor to provide continuous measurement of mammalian cell density inside of disposable, pre-sterilized bag bioreactors which have become an important new type of cell culture vessel for the production of monoclonal antibodies. Cell density is a key parameter for cell culture process diagnostic and optimization purposes. At present there is no available instrumentation for monitoring cell density in disposable bag bioreactors. The new optically based cell density measurement approach provides a simple and reliable method for in situ monitoring cell density inside of plastic bag bioreactors. The measurement approach can also be applied to other types of cell culture vessels including spinner flasks, T-flasks, and roller bottles that are also used grow mammalian cell cultures used for the production of monoclonal antibodies. The new cell density monitor will find applications in both research and production scale cell culture processes for producing monoclonal antibodies where the monitor will help increase the speed of process development and help optimize the process yields through improved process control.

* information listed above is at the time of submission.

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