Absorbable Gels for Modulated Bioavailability of Vaccines

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$69,828.00
Award Year:
1996
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
32831
Agency Tracking Number:
32831
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
6309 Highway 187, Anderson, SC, 29625
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Shalaby W. Shalaby, Ph.d.
(803) 646-8544
Business Contact:
() -
Research Institute:
n/a
Abstract
Growing interest in vaccination and diversity of new vaccines which can be administered as a single dose for timely response and prolonged immunity evoked use of absorbable polymers for developing controlled delivery systems. Although absorbable microspheres were explored for controlled delivery of vaccines, poor reproducibility of these systems created a need for a unique single-shot vaccine formulations, which provide timely antibody response and prolonged immunity. Phase I study includes (1) review of available in-house data, that are being generated, on performance of novel gel formers in controlled release of antibiotics, polypeptides, and bovine serum albumin and select suitable compositions for vaccine formulation using ricin toxid (RT) vaccine as a model; (2) synthesis and characterization of selected polymeric compositions; (3) aseptic preparation and characterization of needed formulations; (4) determination of in-vitro release profile of different formulations; (5) determination of vaccine stability in key formulations; (6) completion of an immunization study in mice and determination of antibody response; and (7) use of immunized mice to assess the persistence of protection against an aerosol challenge with RT. Phase I data will be used in designing Phase II plans which emphasize identification, development, and scale-up of one vaccine formulation.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government