Biomimetics for treating biofilm-embedded infections

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$100,000.00
Award Year:
2009
Program:
STTR
Phase:
Phase I
Contract:
W911NF-09-C-0093
Award Id:
90038
Agency Tracking Number:
A09A-004-0108
Solicitation Year:
n/a
Solicitation Topic Code:
Army 09-004
Solicitation Number:
n/a
Small Business Information
170 N. Radnor-Chester Road, Suite 300, Radnor, PA, 19087
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
621470033
Principal Investigator:
Richard Scott
VP Research, PolyMedix
(484) 598-2336
rscott@polymedix.com
Business Contact:
Dawn Eringis
Director, Scientific Affairs
(484) 598-2334
deringis@polymedix.com
Research Institution:
University of Massachusetts, Amherst
Carol Sprague
Office of Grant and Contract A
70 Butterfield Terrace
Amherst, MA, 1003 -9242
(413) 545-0698
Nonprofit college or university
Abstract

Multi-drug resistant (MDR) biofilms are perhaps the most difficult bacterial infections to fight. They require novel antibiotics that operate through new mechanisms which overcome the biofilm environment. We have discovered a class of antibiotics that are novel and have new targets which appear to evade resistance development. One example is already in the clinic to systemically treat Staphyloccal infections, including methicillin-resistant S. aureus. In addition, we have shown compounds in this series are active against bacterial and fungal biofilms. This STTR aims to identify a number of lead candidates with single micromolar activity against A. baumanni, S. epidermidis, E. faecalis, P. aeruginosa, E. coli and their drug/multi-drug resistance strains in Phase I. Active compounds that meet criteria for further evaluation (including those that have been shown previously to be active against drug-resistant S. aureus) will then be tested and optimized in Phase II to treat MDR biofilm infections.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government