THIS RESEARCH IS INTENDED TO PROVIDE NEW SOLUBLE PLASTIC EMBEDDING RESINS USEFUL IN PREPARING MORPHOLOGICALLY SUPERIOR TISSUE SECTIONS FOR ELECTRON AND LIGHT MICROSCOPY.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1984
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
1494
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Polysciences Inc.
400 Valley Road, Warrington, PA, 18976
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
JACK RADELL
TECHNICAL DIRECTOR
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
THIS RESEARCH IS INTENDED TO PROVIDE NEW SOLUBLE PLASTIC EMBEDDING RESINS USEFUL IN PREPARING MORPHOLOGICALLY SUPERIOR TISSUE SECTIONS FOR ELECTRON AND LIGHT MICROSCOPY. THESE POLYMERS WHICH ARE NOT CROSS-LINKED ARE AMENABLE TO A MILD SOLVENT TREATMENT WHICH ALLOWS PENETRATION BY IMMUNOGLOBULINS AND OTHER TISSUE MARKERS WHICH ARE OF GREAT CURRENT INTEREST. SUCH AN EMBEDDING RESIN WILL MINIMIZE THE PATIENT COST AND THE AMOUNT OF PATIENT BIOPSY TISSUE AND AT THE SAME TIME INCREASE THE DIAGNOSTIC VALUE FROM A SINGLE EMBEDDED BLOCK. OUR APPROACH PROPOSES THE DEVELOPMENT OF POLYMERS WHICH ARE E-BEAM STABLE AND CAPABLE OF BEING THIN SECTIONED THUS ALLOWING THE PHYSICAL PROPERTIES NECESSARY FOR ELECTRON MICROSCOPY AND LIGHT MICROSCOPY MICROTOMY. THIS WILL BE ACCOMPLISHED BY INCORPORATING INTO THE POLYMERIC COMPOSITIONS AROMATIC NUCLEI WHICH RENDER THE POLYMER ELECTRON BEAM STABLE. BY ADJUSTING COPOLYMER COMPOSITION: THE HARDNESS, SOLUBILITY, CHEMICAL AND STAINING CHARACTERISTICS OF THE POLYMER WILL BE MODIFIED TO YIELD THE DESIRED SECTIONING PROPERTIES. THE COMMERCIAL ACCEPTANCE OF EMBEDDING MEDIA WHICH MEETS THE CRITERIA WE HAVE PROPOSED IS VERY PROMISING AS RESEARCHERS AND CLINICAL LABORATORIES HAVE NEED OF SAME FOR THIN IMMUNODIAGNOSTIC TEST PROCEDURES.

* information listed above is at the time of submission.

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