AN ORAL VACCINE AGAINST ENTEROTOXIGENIC E. COLI

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1988
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
7901
Agency Tracking Number:
7901
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
30 Corporate Woods, Rochester, NY, 14623
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
DIARRHEA IS A MAJOR CAUSE OF MORBIDITY AND MORTALITY IN DEVELOPING COUNTRIES, ESPECIALLY IN INFANTS AND YOUNG CHILDREN. ENTEROTOXIGENIC E. COLI (ETEC) CAUSE A SIGNIFICANT PROPORTION OF THIS DISEASE, AS WELL AS EPISODES OF ACUTE DIARRHEA EXPERIENCED BY TRAVELERS TO LESS DEVELOPEDCOUNTRIES. ALL ETEC STRAINS PRODUCE HEAT-LABILE TOXIN (LT),HEAT STABLE TOXIN (ST), OR BOTH. THE IMPORTANCE OF LT AND ST NEUTRALIZING ANTIBODIES AND STIMULATION OF SECRETORY IMMUNITY IN THE PREVENTION OF DIARRHEAL DISEASE IS WELL DOCUMENTED. THUS, AN EFFECTIVE VACCINE AGAINST ETEC WILL CONTAIN IMMUNOGENIC, NONTOXIC FORMS OF LT AND ST. WE PROPOSE TO CONSTRUCT STRAINS OF ATTENUATED SALMONELLA EXPRESSING LT-B/ST FUSION PROTEINS CAPABLE OF ELICITING AN ANTITOXIN SECRETORY IMMUNE RESPONSE. THE RESULTS OF THIS WORK WILL BE USED TO ASSESS THE POTENTIAL FOR MANUFACTURING AND COMMERCIALIZING AN EFFICACIOUS, MULTIVALENT VACCINE FOR ETEC. IF THE APPROACH IS SUCCESSFUL, ADDITIONAL PROTECTIVE EPITOPES FROM ETEC STRAINS AND OTHER DIARRHEAL PATHOGENS COULD BE ADDED.

* information listed above is at the time of submission.

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