Third World Diagnostics--A One-Step Immunoassay for TSH

Award Information
Agency:
Department of Health and Human Services
Amount:
$73,520.00
Program:
SBIR
Contract:
1 R43 HD31379-1,
Solitcitation Year:
N/A
Solicitation Number:
N/A
Branch:
N/A
Award Year:
1994
Phase:
Phase I
Agency Tracking Number:
24950
Solicitation Topic Code:
N/A
Small Business Information
Princeton Biomeditech
4242 U.S., Route 1, Monmouth Junction, NJ, 08852
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
N/A
Principal Investigator
 Jemo Kang
 (908) 274-1000
Business Contact
Phone: () -
Research Institution
N/A
Abstract
Our goal is to develop a self-performing, one-step, semi-quantitative, visual immunometric assayfor human TSH. This assay will use whole blood as a substrate and indicate whether serum levels ofTSH in excess of 5 IU/ml are present. It will contain a built-in control to indicate successful assaycompletion. This assay will be helpful as a screen for neonatal hypothyroidism, especially in populationsthat lack the technological infrastructure required to perform currently available TSH assays. It will alsobe used to screen samples in a cost-effective fashion for the presence of an elevated TSH and thusindicate whether a sample requires a more expensive quantitative TSH assay. By allowing TSHmeasurement to be performed outside of a laboratory and by providing a screening method o detect anelevation in TSH, this assay represents a significant technical innovation. Because of its low cost andease of use, it will have considerable commercial application as a replacement for more expensive andcumbersome radio-, enzyme-linked, fluorescent, and chemiluminescent immunoassays.

* information listed above is at the time of submission.

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