CCD CAMERA SYSTEM FOR X-RAY DIFRACTION IMAGING

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 11383
Amount: $500,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1991
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Princeton Scientific Instrumnt
306 Alexander St, Princeton, NJ, 08540
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THIS PROJECT WILL INVESTIGATE THE ADVANTAGES OF A NEW 2,048 X 2,048-PIXEL CCD-TYPE SOLID-STATE IMAGE SENSOR FOR X-RAY DIFFRACTION APPLICATIONS ON BIOLOGICAL MACROMOLECULES. THE CCD WILL BE FIBEROPTICALLY COUPLED DIRECTLY TO AN X-RAY-SENSITIVE PHOSPHOR SCREEN, ELIMINATING THE IMAGE INTENSIFIER NORMALLY EMPLOYED IN SUCH X-RAY DIFFRACTION IMAGING EQUIPMENT. THIS RESULTS IN A SUBSTANTIAL IMPROVEMENT IN SPATIAL RESOLUTION AND DYNAMIC RANGE. THE PROJECT INCLUDES DESIGNING AND BUILDING THE FIXTURE FOR MOUNTING THE CCD AND FIBEROPTICS PHOSPHOR SCREEN TOGETHER, CONDUCTING THE EXPERIMENTS, AND ANALYZING THE DATA. THE PHASE I PROGRAM WILL INVESTIGATE THE ADVANTAGES OF THESE NEW IMAGE SENSORS TO X-RAY-DIFFRACTION-RELATED RESEARCH. THE HIGH RESOLUTION AND WIDE DYNAMIC RANGE OF THIS CCD IMAGING SYSTEM IS PARTICULARLY WELL MATCHED TO THE PROBLEM OF X-RAY LAUE DIFFRACTION FROM PROTEIN CRYSTALS USING SYNCHROTRON-GENERATED POLYCHROMATIC X-RAYS AND PROTEINDIFFRACTION FROM LARGE UNIT CELLS, A PHASE II EFFORT.

* information listed above is at the time of submission.

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