CCD CAMERA SYSTEM FOR X-RAY DIFRACTION IMAGING

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$500,000.00
Award Year:
1991
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
11383
Agency Tracking Number:
11383
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
306 Alexander St, Princeton, NJ, 08540
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institute:
n/a
Abstract
THIS PROJECT WILL INVESTIGATE THE ADVANTAGES OF A NEW 2,048 X 2,048-PIXEL CCD-TYPE SOLID-STATE IMAGE SENSOR FOR X-RAY DIFFRACTION APPLICATIONS ON BIOLOGICAL MACROMOLECULES. THE CCD WILL BE FIBEROPTICALLY COUPLED DIRECTLY TO AN X-RAY-SENSITIVE PHOSPHOR SCREEN, ELIMINATING THE IMAGE INTENSIFIER NORMALLY EMPLOYED IN SUCH X-RAY DIFFRACTION IMAGING EQUIPMENT. THIS RESULTS IN A SUBSTANTIAL IMPROVEMENT IN SPATIAL RESOLUTION AND DYNAMIC RANGE. THE PROJECT INCLUDES DESIGNING AND BUILDING THE FIXTURE FOR MOUNTING THE CCD AND FIBEROPTICS PHOSPHOR SCREEN TOGETHER, CONDUCTING THE EXPERIMENTS, AND ANALYZING THE DATA. THE PHASE I PROGRAM WILL INVESTIGATE THE ADVANTAGES OF THESE NEW IMAGE SENSORS TO X-RAY-DIFFRACTION-RELATED RESEARCH. THE HIGH RESOLUTION AND WIDE DYNAMIC RANGE OF THIS CCD IMAGING SYSTEM IS PARTICULARLY WELL MATCHED TO THE PROBLEM OF X-RAY LAUE DIFFRACTION FROM PROTEIN CRYSTALS USING SYNCHROTRON-GENERATED POLYCHROMATIC X-RAYS AND PROTEINDIFFRACTION FROM LARGE UNIT CELLS, A PHASE II EFFORT.

* information listed above is at the time of submission.

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