THE PURPOSE OF THIS RESEARCH IS TO DEVELOP A RAPID, SIMPLE, INEXPENSIVE, AND SENSITIVE FLUORESCENCE POLARIZATION IMMUNOASSAY SYSTEM THAT CAN BE USED IN THE DOCTOR'S OFFICE TO MONITOR DRUGS AND HORMONES IN THE SERA OF A PATIENT DURING HIS VISIT.

Award Information
Agency:
Department of Health and Human Services
Branch:
N/A
Amount:
$43,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
N/A
Agency Tracking Number:
4677
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Princeton Separations Inc
37 Nottingham Road, Englishtown, NJ, 07726
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
N/A
Principal Investigator
 DR PAUL T NIX
 PRINCIPAL INVESTIGATOR
 (201) 972-9375
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE PURPOSE OF THIS RESEARCH IS TO DEVELOP A RAPID, SIMPLE, INEXPENSIVE, AND SENSITIVE FLUORESCENCE POLARIZATION IMMUNOASSAY SYSTEM THAT CAN BE USED IN THE DOCTOR'S OFFICE TO MONITOR DRUGS AND HORMONES IN THE SERA OF A PATIENT DURING HIS VISIT. THE FLUORESCENCE POLARIZATION IMMUNOASSAYSYSTEM CAN DETECT ANALYTES IN SERA IN THE MICROGRAM PER MILLILITER TO SUBNANOGRAM PER MILLILITER RANGE WITH A PROCEDURE REQUIRING LESS THAN FIVE MINUTES. IT IS A HOMOGENEOUS ASSAY THAT OVERCOMES THE LIMITATIONS OF FLUORESCENCE IMMUNOASSAY MEASUREMENTS BY USING SPECIAL PROBES AND ELIMINATING NON-SPECIFIC BINDING OF PROBES AND ANALYTES. PRINCETON SEPARATIONS, INC. HAS AIMED TO SHOW THAT THREE ANALYTES (DIPHENYLHYDANTOIN, THYROXINE, AND DIGOXIN) CAN BE DETECTED IN SERA WITH COEFFICIENTS OF VARIATION OF LESS THAN 10% USING A DEDICATED, INEXPENSIVE, AND SIMPLE FLUORESCENCE POLARIZATION INSTRUMENT SUITABLE FORUSE IN THE DOCTOR'S OFFICE. NO PHYSICAL SEPARATION OR PRETREATMENT OF SERA IS REQUIRED. SUCCESSFUL COMPLETION OF THESE GOALS WILL HELP SATISFY THE NEED FOR NON-HOSPITAL DRUGMONITORING FOR THE INCREASING POPULATION OF OLDER AMERICANS.

* information listed above is at the time of submission.

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