Advanced Visualization Techniques for Functional Imagery in Neurodevice Surgical

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43NS060203-01A1
Agency Tracking Number: NS060203
Amount: $173,756.00
Phase: Phase I
Program: SBIR
Awards Year: 2008
Solitcitation Year: 2008
Solitcitation Topic Code: N/A
Solitcitation Number: PHS2007-2
Small Business Information
PRISM CLINICAL IMAGING, INC., 10437 Innovation Dr. Suite 403, Wauwatosa, WI, 53226
Duns: 190899638
Hubzone Owned: Y
Woman Owned: Y
Socially and Economically Disadvantaged: Y
Principal Investigator
 (414) 727-1930
Business Contact
Phone: (414) 727-1930
Research Institution
DESCRIPTION (provided by applicant): Neurodevices are finding application in many neurological disorders, offering hope in situations where conventional non-surgical treatments are ineffective or unavailable. Surgical procedures often involve intraoperativ e determination of optimal electrode placement, a lengthy undertaking often requiring trial- and-error evaluation of potential sites with a conscious, cooperative patient. Recent interest in the application of functional imaging, including functional magne tic resonance imaging (fMRI), to this problem has produced promising results. We will develop, design and evaluate a neurodevice pre- surgical planning and follow-up system utilizing functional imaging intended to assist in cortical electrode placement. Th e input to our system will be multiple images from computed tomography (CT) and magnetic resonance imaging (MRI) systems, particularly functional magnetic resonance imaging (fMRI) studies. The final product will be a modular extension to our FDA-cleared Pr ism View software package, compatible with MRI systems currently used for brain imaging. We will demonstrate feasibility in Phase I by developing means for visualizing functional, physiologic and anatomical data in a fashion particularly suitable to plann ing cortical electrode placement and visualizing post-surgical results. We will be, and evaluating our system in a study of a small number of subjects. In Phase II, we will further refine our software tools, possibly expanding their application for other n eurodevices; investigate additional features such as field modeling of stimulators; and evaluate our system in a larger cohort of subjects to more rigorously evaluate accuracy and precision in predicting optimal electrode placement. Greater confidence will be achieved in utilizing pre-surgical functional imaging to reduce the need for intraoperative electrophysiological testing, and this should translate to reduced operative times. Our initial focus is on applications involving fMRI and epidural cortical el ectrodes. However, it is expected that the technology will also be applicable to functional imaging by transcranial magnetic stimulation (TMS) and magnetoencephalography (MEG); implantation of deep brain stimulation (DBS) devices; and ultimately modeling o f stimulator field effects to support virtual neurodevice evaluation. We will develop, design and evaluate a pre-surgical planning and post-surgical follow-up system for neurodevice applications utilizing functional imaging. Our initial target application applies functional magnetic resonance imaging to cortical electrode placement. If successful, potential health benefits of this system include reduced operative time for neurodevice installation, increasing patient comfort and reducing risk; improved devic e functionality due to better electrode placement. Cost benefits are associated with reduced operative time.

* information listed above is at the time of submission.

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