SYNTHESIS OF ETIOCHOLANOLONE FOR USE IN APLASTIC ANEMIA

Award Information
Agency:
Department of Health and Human Services
Amount:
$495,000.00
Program:
SBIR
Contract:
N/A
Solitcitation Year:
N/A
Solicitation Number:
N/A
Branch:
N/A
Award Year:
1986
Phase:
Phase II
Agency Tracking Number:
2958
Solicitation Topic Code:
N/A
Small Business Information
Progenics, Inc.
442 West 44nd Street, New York, NY, 10036
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
N/A
Principal Investigator
 Norman Applezweig
 Principal Investigator
 (212) 265-0650
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE USE OF -ETIOCHOLANOLONE AND -ETIOCHOLANOLONE IN APLASTIC ANEMIA SHOWS PROMISE, BUT THE SUPPLY IS VERY LIMITED DUE TO THE LACK OF A GOOD SYNTHESIS FROM READILY AVAILABLE MATERIAL. -ETIOCHOLANOLONE WOULD BE LESS TRAUMATIC TO THE PATIENT, BUT IS NOT READILY AVAILABLE AGAIN FOR THE ABOVE MENTIONED REASON. DURING PHASE I, REASONABLE AND ECONOMIC SYNTHESES OF -ETIOCHOLANOLONE AND -ETIOCHOLANOLONE FROM READILY AVAILABLE RAW MATERIALS HAVE BEEN SUCCESSFULLY DEVELOPED THUS PERMITTING THE SYNTHESIS OF SUFFICIENT QUANTITIES OF THESE AGENTS FOR LARGE-SCALE CLINICAL TRIALS. PHASE II FUNDS ARE BEING SOUGHT TO CARRY OUT CLINICAL TRIALS IN APLASTIC ANEMIA AS WELL AS TOXICOLOGY STUDIES WITH COMPETENT INVESTIGATORS.

* information listed above is at the time of submission.

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