PROGENRA, INC.

Company Information

Company Name
PROGENRA, INC.
Address
271A GREAT VALLEY PKWY
271A GREAT VALLEY PKWY
MALVERN, PA, 19355-
Phone
n/a
URL
n/a
DUNS
190641816
Number of Employees
n/a

Award Totals

PROGRAM/PHASE
AWARD AMOUNT ($)
NUMBER OF AWARDS
SBIR Phase I
$6,513,958.00
25
SBIR Phase II
$6,955,152.00
6
Chart code to be here

Award List

  1. USP34 as a novel target for treatment of idiopathic pulmonary fibrosis

    Amount: $265,823.00

    DESCRIPTION (provided by applicant): Aberrant overactivation of WNT signaling appears to play a major role in Idiopathic Pulmonary Fibrosis (IPF). Inhibitors of overactivated WNT signaling are candida ...

    SBIR Phase I 2010 Department of Health and Human Services
  2. Targeting SUMO proteases for type II diabetes

    Amount: $271,286.00

    DESCRIPTION (provided by applicant): Type 2 diabetes mellitus (T2D) has an enormous physical and economic impact worldwide. Despite current treatments, T2D often ultimately requires insulin replacemen ...

    SBIR Phase I 2010 Department of Health and Human Services
  3. Molecular screen for isopeptidase inhibitors to treat pulmonary disease

    Amount: $984,638.00

    DESCRIPTION (provided by applicant): With the approval of the proteasome inhibitor Velcade for multiple myeloma therapy, the ubiquitin pathway has been validated for drug discovery. An alternative ubi ...

    SBIR Phase II 2010 Department of Health and Human Services
  4. Screen For Inhibitors of Parkin E3 Autoubiquition

    Amount: $328,269.00

    DESCRIPTION (provided by applicant): Neurodegenerative disease represents a major challenge to the maintenance of health and quality of life in diverse segments of the population. Among the various d ...

    SBIR Phase I 2003 Department of Health and Human Services
  5. Osteoporosis Screen for Praja 1 E3 Ligase Inhibitors

    Amount: $149,800.00

    DESCRIPTION (provided by applicant): 0steoporosis represents a major challenge to the maintenance of health and quality of life in an aging population. Among the most promising and least exploited the ...

    SBIR Phase I 2004 Department of Health and Human Services
  6. Osteoporosis Screen for Praja1 E3 Ligase Inhibitors

    Amount: $1,247,991.00

    DESCRIPTION (provided by applicant): Osteoporosis remains a major challenge to the maintenance of health and quality of life in an aging population. Among the most promising and least exploited therap ...

    SBIR Phase II 2007 Department of Health and Human Services
  7. Screen for MURF-1 inhibitors to treat myopathy

    Amount: $266,848.00

    DESCRIPTION (provided by applicant): Myopathy (muscle atrophy, or muscle wasting) is a serious clinical complication of cancer, HIV/AIDS, diabetes, and other chronic diseases, leading to increased mor ...

    SBIR Phase I 2005 Department of Health and Human Services
  8. Molecular Screens for Deubiquitinase Function

    Amount: $363,348.00

    DESCRIPTION (provided by applicant): A key aspect of cellular regulation that affords a number of potential opportunities for pharmacological intervention is the maintenance of protein homeostasis. P ...

    SBIR Phase I 2005 Department of Health and Human Services
  9. Molecular screens for pVHL-associated isopeptidase VDU1

    Amount: $243,124.00

    DESCRIPTION (provided by applicant): VDU1 is a recently described ubiquitin isopeptidase that binds to and is ubiquitinated by the E3 ligase complex of the vonHippel-Lindau protein (pVHL). VDU1 has ...

    SBIR Phase I 2005 Department of Health and Human Services
  10. Ubiquitin ligase as a therapeutic target for arthritis

    Amount: $278,569.00

    DESCRIPTION (provided by applicant): Rheumatoid arthritis (RA) is associated with chronic inflammation and overgrowth of synovial cells, and factors involved in these processes are potential targets f ...

    SBIR Phase I 2006 Department of Health and Human Services

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