NOVEL CREATINE SUPPLEMENTS FOR ENHANCING MUSCLE FUNCTON

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$131,154.00
Award Year:
2002
Program:
SBIR
Phase:
Phase I
Contract:
1R43AT001145-01
Award Id:
59811
Agency Tracking Number:
AT001145
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
PRONUTRIENT TECHNOLOGIES, INC., 5601 S 27TH ST, STE 202, LINCOLN, NE, 68512
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
HUAIYUN HAN
(402) 559-5383
HHAN@UNMC.EDU
Business Contact:
SAMUEL AUGUSTINE
(402) 559-5774
SAUGUSTI@UNMC.EDU
Research Institute:
n/a
Abstract
This proposal will demonstrate the feasibility of creating and formulating a dietary supplement of creatine with improved oral absorption characteristics. Such an improvement would allow increased use of creatine supplement to augment and complement existing treatments for conditions where muscle fatigue and weakness are a problem. It is known that increasing dietary intake of creatine can improve muscle function by increasing creatine phosphate levels in the cell. However, due to limited oral absorption, current embodiments of creatine dietary supplements require the administration of large doses that often result in undesired side-effects such as bloating, cramping and diarrhea. It is hypothesized that by chemically modifying creatinine to form creatine esters (CE), novel supplements with improved oral absorption and muscle performance and muscle performance can be obtained. The specific aims of this proposal are to synthesize a series of CE compounds and through in vitro screening assays and in vivo pharmacokinetic studies, determine which one(s) have improved oral absorption compared to creatine monohydrate, the current preferred form of dietary supplement. Finally, suitable liquid and solid dietary supplement formulations will be identified for the lead CE compound. This Phase I proposal will provide proof-of-concept supplements have improved oral absorption over products current available.

* information listed above is at the time of submission.

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