SUPERCRITICAL FLUID SOLVENT SYSTEM FOR SOLID PHASE PEPTIDE SYNTHESIS

Award Information
Agency:
National Aeronautics and Space Administration
Branch
n/a
Amount:
$50,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
5041
Agency Tracking Number:
5041
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
1700 E. 18th Street, Suite 102, Tucson, AZ, 85719
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
Dr. Leon E. Barstow
Investigator
() -
Research Institution:
n/a
Abstract
SYNTHETIC PEPTIDES ARE WIDELY USED AS HORMONES, VACCINES ANDOTHER POTENT NEW PHARMACEUTICALS. METHODS OF SYNTHESIS DIFFER RADICALLY WHETHER SOLUTION PHASE OR SOLID PHASE CHEMISTRY IS USED. THIS SBIR PROPOSAL DEALS WITH SOLID PHASE SYNTHESIS, WHILE A SEPARATE SBIR PROPOSAL IS BEING SUBMITTED ON SOLUTION PHASE CHEMISTRY. BOTH AIM AT IMPROVEMENT OF THE SYNTHETIC PROCESSES THROUGH THE USE OF SUPERCRITICAL CO2 (SC-CO2) AS THE REACTION MEDIUM. WHILE THE UNIQUE PROPERTIES OF SUPERCRITICAL FLUIDS (SCF) HAVE BEEN KNOWN FOR A LONG TIME, INTENSIVE RESEARCH IN SCF USAGE IS ONLY OF RECENT VINTAGE. MOST APPLICATIONS OF SCF ARE IN EXTRACTIVE PROCESSES, RATHER THAN CHEMICAL SYNTHESIS,AND NONE HAS YET BEEN TRIED FOR PEPTIDE SYNTHESIS. SC-CO2 IS PARTICULARLY INTERESTING BECAUSE OF ITS LOW CRITICAL TEMPERATURE, 31.12C, SOLVENT WHICH COULD BE GENERATED IN SPACE OR ON MOON FROM LOCALLY AVAILABLE RESOURCES. THUS, A VARIETY OF SCF PROCESSES MAY BECOME OF IMPORTANCE TO NASA. WE WISH TO STUDY THE SYNTHESIS OF PEPTIDES BECAUSE OF THEIR VERY HIGH VALUE PER UNIT WEIGHT, GREAT ECONOMIC AND SOCIO-MEDICAL VALUE AND THE POSSIBILITY OF ACHIEVING SIGNIFICANT IMPROVEMENT OF THE PROCESS IN MICROGRAVITY.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government