IMMUNOASSAY FOR HUMAN PROGESTERONE RECEPTOR

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
7205
Agency Tracking Number:
7205
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
1858 Star Batt Drive, Rochester, MI, 48063
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
NAOMI ELIEZER PHD
(313) 852-1067
Business Contact:
() -
Research Institute:
n/a
Abstract
PROGESTERONE RECEPTOR IS ONE OF A GROUP OF STEROID HORMONE RECEPTORS THAT HAS BEEN SHOWN TO HAVE IMPORTANT REGULATORY EFFECTS IN MAMMARY AND OTHER TARGET TISSUES. THE QUALITATIVE AND QUANTITATIVE DETERMINATION OF PROGESTERONE RECEPTOR IS USEFUL IN THE THERAPEUTIC MANAGEMENT OF BREAST CANCER. CURRENTLY, AVAILABLE ASSAYS FOR PROGESTERONE RECEPTOR HAVE DRAWBACKS THAT MAKE THEM DIFFICULT TO USE IN MOST CLINICAL LABORATORIES. THE MAJOR LONG-TERM GOALS OF THIS PROPOSAL ARE THE DEVELOPMENT OF A SENSITIVE, RELIABLE, ENZYME-LINKED IMMUNOASSAY FOR PROGESTERONE RECEPTOR, THE PRODUCTION OF MONOCLONAL ANTIBODIES CAPABLE OF DISTINGUISHING AMONG THE VARIOUS FORMS OF THE RECEPTOR, AND THE ISOLATION OF PURIFIEDHUMAN PROGESTERONE RECEPTOR USING AN IMMUNOAFFINITY RESIN PREPARED WITH ONE OF THE ABOVE MONOCLONAL ANTIBODIES.

* information listed above is at the time of submission.

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