SPECIFIC PROTEINS

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
4286
Agency Tracking Number:
4286
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
12301 Parklawn Dr, Rockville, MD, 20852
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
DR NORMAN G ANDERSON
(301) 231-5528
Business Contact:
() -
Research Institute:
n/a
Abstract
THE OBJECTIVE IS TO DEVELOP RAPID, SPECIFIC, AND SENSITIVE METHODS FOR DETECTING, LOCALIZING, AND QUANTITATING THE EFFECTS OF TRAUMA, OF CHEMICAL OR BIOCHEMICAL TOXIC AGENTS, OF IONIZING RADIATION, OR OF INFECTION IN INJURED, EXPOSED, OR INFECTED MILITARY PERSONNE. WE PROPOSED TO IDENTIFY SYSTEMATICALLY PROTEINS SPECIFIC TO ORGANS, TISSUES, CELL TYPES OR INFECTIOUS AGENTS USING HIGH RESOLUTION TWODIMENSIONAL ELECTROPHORESIS AND COMPUTERIZED IMAGE ANALYSIS AND DATA REDUCTION. CANDIDATE MARKER PROTEINS RECOVERED FROM GELS WILL BE USED TO PRODUCE ANTIBODIES, AND TESTS BASED ON THEM USED FOR DISEASE, INFECTION, OR INJURY-RELATED CELL LEAKAGE DETECTION IN PLASMA OR URINE. PHASE I FEASIBILITY STUDIES WILL BE DONE IN MICE, WHILE PHASE II STUDIES WILL BE RAPIDLY EXTENDED TO MAN. WE HAVE DEVELOPED THE REQUISITE METHODS FOR RUNNING LARGE NUMBERS OF 2-D ANALYSES, FOR COMPUTERIZED INTERCOMPARISON OF 2-D MAPS, FOR ISOLATING PROTEIN FROM SPOTS OF INTEREST, AND FOR PRODUCING POLYVALENT ANTIBODIES AGAINST THE PROTEINS RECOVERED.

* information listed above is at the time of submission.

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