HIGH-RESOLUTION, TWO-DIMENSIONAL ELECTROPHORESIS ALLOWS A LARGE FRACTION OF THE ESTIMATED 30,000 TO 50,000 HUMAN PROTEINS TO BE IDENTIFIED BY MAP POSITION AND TO BE QUANTITATED.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4774
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1986
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Proteus Technologies Inc
12301 Parklawn Drive, Rockville, MD, 20852
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 NORMAN G ANDERSON
 PRINCIPAL INVESTIGATOR
 (301) 881-2600
Business Contact
Phone: () -
Research Institution
N/A
Abstract
HIGH-RESOLUTION, TWO-DIMENSIONAL ELECTROPHORESIS ALLOWS A LARGE FRACTION OF THE ESTIMATED 30,000 TO 50,000 HUMAN PROTEINS TO BE IDENTIFIED BY MAP POSITION AND TO BE QUANTITATED. NORMAL AND CANCER CELLS HAVE BEEN MAPPED IN ORIENTING STUDIES AND MANY DIFFERENCES FOUND. TO GIVE MEANING TO THSES RESULTS, AND TO SYSTEMATICALLY EXPLOIT THEM, A LARGE DATABASE (THE CANCER PROTEIN DATABASE) INCLUDING ALL AVAILABLE DATA ON EACH SPOT IS REQUIRED, WITH THE DATABASE DIRECTLY LINKED TO CRT MAP DISPLAYS. THE DATABASE WILL INCLUDE (FOR EACH PROTEIN) INTRACELLULAR LOCATION, TYPES OF CELLS IN WHICH FOUND, NAMES, FUNCTIONS, DISEASE CORRELATION, BIOPHYSICAL DATA, LITERATURE CITATIONS,MEMBERSHIP IN COREGULATED SETS, DIFFERENTIATIONAL STAGE OF OCCURRENCE, AND CHROMOSOMAL LOCATION OF THE CODING GENE. THE THESES TO BE EXPLORED ARE THAT CELLS ARE HIGHLY INTEGRATED SYSTEMS TO BE UNDERSTOOD IN TERMS OF PROTEIN SETSAND THE REGULATIONAL CIRCUITS INVOLVING THEM, AND THAT COMPOSITIONAL CHANGES IN CANCER CELLS ARE NOT RANDOM, BUT REFLECT ALTERATIONS IN NORMAL REGULATIONAL AND DIFFERENTIA- TIONAL FUNCTIONS. THIS PHASE I PROJECT IS FOR THE CONTINUEDDEVELOPMENT OF THE TYCHO AND KEPLER DATABASE SYSTEMS, SPECIFICALLY DIRECTED TO CANCER STUDIES, IN A PRIVATE SETTING.

* information listed above is at the time of submission.

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government