THERAPEUTIC USE OF INTER-ALPHA INHIBITOR IN SEPSIS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43GM065667-01
Agency Tracking Number: GM065667
Amount: $143,105.00
Phase: Phase I
Program: SBIR
Awards Year: 2002
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
PROTHERA BIOLOGICS, LLC
PROTHERA BIOLOGICS, LLC, 87 WALMER AVE, EAST PROVIDENCE, RI, 02914
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 YOWPIN LIM
 (401) 444-5416
 YOW-PIN_LIM_MD@BROWN.EDU
Business Contact
 YOW-PIN LIM
Phone: (401) 438-2949
Email: YOW-PIN_LIM_MD@BROWN.EDU
Research Institution
N/A
Abstract
The primary goal of this proposed research is targeted towards demonstrating the commercial utilization of human plasma derived inter- alpha inhibitor proteins (IaIp) an effective therapy of sepsis. IaIp are serine protease inhibitors found normally at high levels in human plasma. The fact that no person with complete absence of IaIp has ever been detected suggests an essential physiological role for these proteins. In patients with severe sepsis, the plasma level of IaIp decrease significantly and the decrease correlates with mortality. We propose that administration of IaIp to restore the imbalance between these natural protective inhibitors and destructive proteases will prevent organ injuries and ultimately reduce sepsis related mortality. Our preliminary animal studies in a sepsis rat model of cecal ligation and puncture (CLP) have demonstrated the beneficial effects of IaIp in maintaining hemodynamic stability, preventing organ injury, and improving survival during sepsis. In this study, we propose to optimize a protocol for purification of IaIp from human crude plasma and to evaluate and confirm the beneficial effects of the purified IaIp in the CLP rat model. The ultimate goal of these studies is to develop a novel plasma derived therapeutic that is safe and effective for sepsis.

* information listed above is at the time of submission.

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