Reagents for Drug Toxicity Studies Using Megakaryocytes

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 CA63978-1,
Agency Tracking Number: 24872
Amount: $80,998.00
Phase: Phase I
Program: SBIR
Awards Year: 1994
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
7581 Lindbergh Drive, Gaithersburg, MD, 20879
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Ronald Brown
 (301) 840-9331
Business Contact
Phone: () -
Research Institution
The development of hematopoietic defined protein-free reagents that support megakaryocyteformation will be of inestimatable importance. The rationale for developing such reagents is that it willallow the measurement of drug toxicity in its unbound state in which all of the drug is active. Thereagents will be uniform standard reagents for such assays, save investigator time and effort indeveloping such reagents and facilitate drug evaluation free of bond drug. This research combinesthe strengths of two laboratories, one skilled in development of protein-free and serum-free reagentsand the other in megakaryocyte assay. Such a combination should bode well for the success of thisproposal. The Phase I effort will focus on the development of defined reagents for a murinemegakaryocyte assays. The Phase II effort will focus on the development of defined reagants forhuman megakaryocyte assays.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government