Clinical Reagents for Peripheral Blood Stem Cells

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 HL53804-01,
Agency Tracking Number: 29502
Amount: $750,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1997
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
7581 Lindbergh Drive, Gaithersburg, MD, 20879
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Ronald Brown
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
We will develop fully defined, serum-free culture reagents, which contain no components of non- humwhich can be produced under completely controlled and reproducible pharmaceutical standards, and whiwith recombinant human hematopoietic factors will successfully support the generation and expansionprogenitor cells in-vitro from normal human marrow or blood mononuclear cells in short-term suspensidefine, develop and carry out initial preclinical evaluation of fully-defined, serum-free culture recomponents of non-human origin, to be used for culture of normal human hematopoietic progenitor cellbe to use successful serum-free reagents that have been shown to support hematopoietic stem cell expcontain components of non-human origin which will be sequentially replaced with components that areapproved. Development of these tissue culture reagents will focus on a specific clinical applicationand expansion of late neutrophil progenitors for infusion into patients undergoing autologous bone mblood stem cell transplantation in order to prevent or abate profound neutropenia in these patients.

* Information listed above is at the time of submission. *

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