Clinical Reagents for Peripheral Blood Stem Cells

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$750,000.00
Award Year:
1997
Program:
SBIR
Phase:
Phase II
Contract:
1 R43 HL53804-01,
Award Id:
29502
Agency Tracking Number:
29502
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
7581 Lindbergh Drive, Gaithersburg, MD, 20879
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Ronald Brown
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
We will develop fully defined, serum-free culture reagents, which contain no components of non- humwhich can be produced under completely controlled and reproducible pharmaceutical standards, and whiwith recombinant human hematopoietic factors will successfully support the generation and expansionprogenitor cells in-vitro from normal human marrow or blood mononuclear cells in short-term suspensidefine, develop and carry out initial preclinical evaluation of fully-defined, serum-free culture recomponents of non-human origin, to be used for culture of normal human hematopoietic progenitor cellbe to use successful serum-free reagents that have been shown to support hematopoietic stem cell expcontain components of non-human origin which will be sequentially replaced with components that areapproved. Development of these tissue culture reagents will focus on a specific clinical applicationand expansion of late neutrophil progenitors for infusion into patients undergoing autologous bone mblood stem cell transplantation in order to prevent or abate profound neutropenia in these patients.

* information listed above is at the time of submission.

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