STM/AFM ON BIOLOGICAL MATERIALS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 8118
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1988
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
77 N Oak Knoll Ave #114, Pasadena, CA, 91101
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
MECHANICAL IMAGING SYSTEMS SUCH AS THE SCANNING TUNNELING MICROSCOPE (STM) AND THE ATOMIC FORCE MICROSCOPE (AFM) HAVE TREMENDOUS POTENTIAL FOR IMAGING BIOLOGICAL SAMPLES AND BIOMOLECULES. STM AND AFM HAVE ATOMIC RESOLUTION AND ARE DEMONSTRATED TO WORK IN AMBIENT ATMOSPHERE, LIQUID AND VACUUM. A MAJOR ADVANTAGE OF THESE TECHNIQUES OVER CONVENTIONAL SUBMICRON IMAGING TECHNIQUES SUCH AS SEM IS THAT SAMPLES CAN BE IMAGED IN SITU. THIS PROPOSAL FOCUSES ON DEVELOPMENTS THAT ARE REQUIRED BEFORE STM CAN BE USED ROUTINELY AS A LABORATORY TOOL FOR STUDYING BIOLOGICAL SAMPLES. TOPICS ADDRESSED ARE TECHNIQUES FOR STUDYING NONCONDUCTING SAMPLES, TECHNIQUES FOR STUDYING SAMPLES IMMERSED IN CONDUCTING LIQUIDS, THE EFFECTS OF INTENSE ELECTRIC FIELDS ON BIOLOGICAL SAMPLE, AND INSTRUMENT AUTOMATION.

* Information listed above is at the time of submission. *

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