A Real-Time, Portable Non-Invasive Monitoring System of Muscle Oxygen and pH in Trauma Patients

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-08-C-0114
Agency Tracking Number: A08A-037-0206
Amount: $99,904.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: A08-T037
Solicitation Number: 2008.A
Timeline
Solicitation Year: 2008
Award Year: 2008
Award Start Date (Proposal Award Date): 2008-07-31
Award End Date (Contract End Date): 2009-02-28
Small Business Information
15 Franklin Circle, Northboro, MA, 01532
DUNS: 827405833
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 Babs Soller
 Principal Investigator
 (508) 856-5904
 babs.soller@umassmed.edu
Business Contact
 John Coates
Title: Co-Investigator
Phone: (203) 426-8495
Email: JohnC79051@aol.com
Research Institution
 UMASS MEDICAL SCHOOL
 Patricia McNulty
 Research Funding Services
55 Lake Ave North
Worcester, MA, 1655
 (508) 856-2119
 Nonprofit college or university
Abstract
Trauma and severe hemorrhage remain the most frequent causes of death in the 1-44 year age group in both the civilian and military settings. Early recognition of shock and prompt institution of appropriate resuscitative measures are widely believed to improve outcome and decrease the progression to multi-system organ failure by virtue of maintaining end-organ perfusion. The physiological response to hemorrhage includes significant vasoconstriction to help maintain adequate perfusion to vital organs. Based on this known physiological response, noninvasive assessment of muscle oxygen and pH can provide a significantly earlier indication of blood loss than the standard vital sign measurements. Near infrared spectroscopy (NIRS) can be used to noninvasively and continuously determine muscle oxygen and pH and has been demonstrated to successfully recognize physiologic changes in a laboratory model of pre-shock (LBNP). Current NIRS systems employing fiber optic light cables are too large and fragile for portable use near the battlefield. This proposal describes novel technology for a portable, spectroscopic monitor to determine muscle oxygen and pH without fiber optic cables. The components of this system will be demonstrated on tissue-like phantom materials, as well as on human subjects. An initial design for a handheld, portable monitor will be completed as part of this Phase I project.

* Information listed above is at the time of submission. *

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