Regulators of Fibroblast Growth Factor Activity

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1993
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
22041
Agency Tracking Number:
22041
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
P. O. Box 2517, St. Louis, MO, 63114
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Phillip J. Anevski
(301) 840-9331
Business Contact:
() -
Research Institute:
n/a
Abstract
TELEPHONE NUMBER: (314) 429-7700 AWARDEE NUMBER: 1 R43 CA61390-01 The overall objective is to develop polysulfated carbohydrate derivatives that will inhibit the action of fibroblast growth factors (FGF). FGF's have been implicated in several human cancers both as angiogenic factors and as growth factors capable of sustaining autonomous cell proliferation. Inhibition of these growth factors could inhibit tumor growth. The project is based on the preliminary observations that polysulfated carbohydrate derivatives, such as pentosan polysulfate, and polysulfated aromatic compounds, such as suramin, inhibit FGF activity and suppress the growth of cancer cells. Initial observations also indicate that heparin-like molecules are required for FGF activity. Specifically, we will synthesize related compounds from carbohydrates with FGF inhibitory activity. Since they are based on natural products, they may have fewer side affects than compounds such as suramin. The advantages of these compounds for clinical use would include ease of administration and chemical homogeneity.

* information listed above is at the time of submission.

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