A MAJOR CONCERN IN ENVIRONMENTAL AND OCCUPATIONAL AIR POLLUTION IS THE HAZARD POSED BY SUSPECTED CARCINOGENS.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
3147
Agency Tracking Number:
3147
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
400 Mississippi Street, Morgantown, WV, 26505
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
GEORGE D. CASE
PRINCIPAL INVESTIGATOR
(304) 291-6706
Business Contact:
() -
Research Institute:
n/a
Abstract
A MAJOR CONCERN IN ENVIRONMENTAL AND OCCUPATIONAL AIR POLLUTION IS THE HAZARD POSED BY SUSPECTED CARCINOGENS. WHEREAS MOST PREVIOUS RESEARCH HAS FOCUSED ON CONCENTRATIONS OR BIOASSAYS OF SPECIFIC CHEMICAL AGENTS, THE PROPOSED DEVELOPMENT OF THE ""C-PROBE'' DIRECT PASSIVE MONITOR OFFERS A GREATLY SIMPLIFIED MEANS TO DETECT THE BIOLOGICAL ACTIVITY OF UNSPECIFIED AGENTS WHICH MAY REFLECT THEIR CARCINOGENIC HAZARD. THE MONITOR IS DESIGNED TO MEASURE, COLORIMETRICALLY OR BY OTHER MEANS, EPOXIDE INTERMEDIATES AND/OR OXIDATION PRODUCTS OF METABOLIC ACTIVATION, IN A COMPACT, SELF-CONTAINED UNIT. THIS PROJECT IS INTENDED TO DEMONSTRATE PROOF OF CONCEPT FOR ""C-PROBE,'' BY PROVIDING DATA ON THE MEASUREMENT OF METABOLIC ACTIVATION OF CARCINOGEN PRECURSORS TO EPOXIDE INTERMEDIATES AND/OR OXIDATION PRODUCTS, AND BY DETERMINING ITS FEASIBILITY WITH SOLID AND LIQUID PHASE ADDITIONS AND AEROSOLS. EXPERIMENTS INVOLVE OPTIMIZING PROCEDURES FOR PREPARING PROTOTYPE ""C-PROBE'' UNITS, WET TESTS TO DETERMINE INDICATOR SENSITIVITY, LOADING REQUIREMENTS FOR THE MICROSOMAL ACTIVATION SEGMENT, AND EFFECTS OF BASELINE ARTIFACTS, DIFFUSION TESTS TO DETERMINE COLOR DEVELOPMENT TIME, AND AEROSOL

* information listed above is at the time of submission.

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