SOFTWARE FOR ANALYSIS OF INCOMPLETE LONGITUDINAL DATA

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 7391
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1987
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Rho Inc
102 Hunter's Ridge Road, Chapel Hill, NC, 27514
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 MW HELMS
 (919) 933-2540
Business Contact
Phone: () -
Research Institution
N/A
Abstract
MEDICAL RESEARCH FREQUENTLY INVOLVES LONGITUDINAL AND/OR MULTIVARIATE MEASUREMENTS; WHEN THE RESEARCH INVOLVES HUMANSOR LABORATORY ANIMALS, THE DATA ARE OFTEN INCOMPLETE OR INVOLVE TIME-DEPENDENT COVARIATES, PROBLEMS THAT TRADITIONALSTATISTICAL TECHNIQUES AND SOFTWARE CANNOT HANDLE PROPERLY. MANY IMPORTANT ADVANCES HAVE BEEN MADE IN STATISTICAL METHODS FOR INCOMPLETE LONGITUDINAL/MULTIVARIATEDATA IN THE PAST 5 TO 10 YEARS, BUT THESE METHODS ARE NOT GENERALLY AVAILABLE TO MEDICAL RESEARCHERS DUE TO A LACK OF HIGH-QUALITY, USER-FRIENDLY COMPUTER SOFTWARE. THE ULTIMATE GOALS OF THIS PROJECT, INCLUDING PHASE II, ARE TO PRODUCE AND MARKET SUCH SOFTWARE FOR USE ON MAINFRAMES AND LARGE MICROCOMPUTERS. THE SOFTWARE WILL IMPLEMENT METHODS FOR LINEAR MODELS WITH LINEAR COVARIANCE STRUCTURE, SUBJECT TO LINEAR CONSTRAINTS, WHICH HAVE BEEN SHOWN TO BE EXTREMELY USEFUL FOR ANALYSIS OF INCOMPLETE MEDICAL RESEARCHDATA. PHASE I WILL INCLUDE RESEARCH TO: (1) SELECT ALGORITHMS FOR THE FUNDAMENTAL COMPUTATIONS; (2) DESIGN OVERALL PROGRAM STRUCTURE; (3) DESIGN TWO USER INTERFACES (MENU AND COMMAND-LANGUAGE DRIVEN) FOR EACH PROGRAM; AND (4) IMPLEMENT, DEBUG, TEST, AND DOCUMENT PROTOTYPE SOFTWARE. PHASE II WILL INCLUDE: (1) RESEARCH WITH THE PROTOTYPE SOFTWARE TO IMPROVE USER INTERFACES AND PROGRAM PERFORMANCE AND (2) DEVELOPMENT OF HIGHLY EFFICIENT, USER-FRIENDLY PRODUCTION SOFTWARE WHICH WILL BE MARKETED.

* information listed above is at the time of submission.

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