IMPROVED TECHNETIUM-99M LABELING FOR CANCER IMAGING

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$500,000.00
Award Year:
1991
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
11163
Agency Tracking Number:
11163
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
1020 Tijeras Ne Ste C, Albuquerque, NM, 87106
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institute:
n/a
Abstract
A NEW METHOD OF DIRECT LABELING OF ANTIBODIES WITH TECHNETIUM-99M (TC-99M) WILL BE DEVELOPED AND EVALUATED. INTHIS METHOD, CALLED THE REGULATED REDUCTION METHOD, ONE CHEMICAL MEANS IS USED TO BREAK THE DISULFIDE BOND IN THE PROTEIN, AND A SEPARATE CHEMICAL MEANS IS USED TO REDUCE THE SODIUM PERTECHNETATE. USING THIS METHOD, TRANSCHELATION IS LOWER, AND HIGHER RADIOCHEMICAL PURITY RESULTS. THE METHOD WILL BE FORMULATED FOR A SIMPLE KIT FORMAT, ALLOWING QUICK LABELING WITH TC-99M WITH A MINIMUM OF STEPS. A NEW AND SIMPLE TC-99M LABELING METHOD WILL HAVE WIDE APPLICATION FOR DIAGNOSTIC IMAGING WITH MONOCLONAL ANTIBODIES. THE REGULATED REDUCTION METHOD WILL BE DEVELOPED USING TWO ANTIBODIES: B72.3, WHICH IS AN IGG, AND ANTI-SSEA-1, WHICH IS AN IGM. THE REGULATED REDUCTION METHOD WILL BE COMPARED TO THE PRETINNING DIRECT LABELING METHOD AND A BIFUNCTIONAL CHELATE METHOD, AND WILL BE TESTED FOR RADIOCHEMICAL PURITY, STABILITY, IMMUNOREACTIVITY, AND TRANSCHELATION.

* information listed above is at the time of submission.

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