DIRECT RADIOMETAL LABELING FOR IMAGING AND THERAPY

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1992
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
19018
Agency Tracking Number:
19018
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Rhomed Inc (Currently Rhomed, Inc.)
4216 Balloon Park Road Ne, Albuquerque, NM, 87109
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Paul O Zamora
(505) 344-7200
Business Contact:
() -
Research Institution:
n/a
Abstract
ANTIBODIES OR ANTIBODY FRAGMENTS, REDUCED AND LYOPHILIZED FOR USE IN PREPARING INSTANT, ONE-STEP TC-99M RADIOPHARMACEUTICALS, CAN ALSO BE LABELED WITH CU-67. THE CU-67, AS CU(II) IN A PH 5.6 BUFFER, IS SIMPLY ADDED TO THE ANTIBODY TO GENERATE THE CU-67-LABELED ANTIBODY. THE PURPOSE OF THIS PROJECT IS TO DETERMINE THE PARAMETERS OF THIS REACTION AND THE PURITY, STABILITY, AND IMMUNO-REACTIVITY OF THE RESULTANT RADIOLABELED PRODUCT. DURING PHASE II, DIRECT LABELING USING CU-67 AND OTHER RADIOMETALS WILL BE EVALUATED AND THE PRODUCTS WILL BE TESTED IN ANIMAL MODELS COMPARED TO THE SAME ANTIBODY LABELED WITH TC-99M. ULTIMATELY, RADIOLABELED ANTIBODIES WILL BE MADE FOR THERAPY AND PET IMAGING STUDIES. THIS APPROACH PERMITS THE SAME ANTIBODY, USING THE SAME LABELING CHEMISTRY, TO BE LABELED WITH SEVERAL DIFFERENT RADIO METALS, INCLUDING TC-99M AND CU-67. PHASE III STUDIES WILL INCLUDE HUMAN TRIALS OF VALIDATED AND CLINICALLY RELEVANT DIAGNOSTIC OR THERAPEUTIC RADIOPHARMACEUTICALS.

* information listed above is at the time of submission.

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