New Reagents and Materials from Highly Reactive Metals

Award Information
Agency:
Department of Health and Human Services
Amount:
$748,790.00
Program:
SBIR
Contract:
N/A
Solitcitation Year:
N/A
Solicitation Number:
N/A
Branch:
N/A
Award Year:
1995
Phase:
Phase II
Agency Tracking Number:
22285
Solicitation Topic Code:
N/A
Small Business Information
Rieke Metals, Inc.
6133 Heide Lane, Lincoln, NE, 68512
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
N/A
Principal Investigator
 Li-Shan Zhu
 (402) 472-9044
Business Contact
Phone: () -
Research Institution
N/A
Abstract
The primary long term objective will be the large scale production of novel organometallic reagents prepared from highly reactive Rieke Metals. Primary metals to be examined include zinc, magnesium, copper, and calcium. The development of highly reactive Rieke Metals allows the direct oxidative addition of these metals to a variety of carbon-halogen bonds to yield many classes of organometallic reagents which previously could not be prepared. In particular, highly functionalized organozinc and organocopper reagents are now possible. Highly reactive magne- sium allows the preparation of difficult to prepare Grignards and a highly significant new organometallic class of reagents: (2-butene-1,4-diyl)magnesium reagents. Highly reactive calcium can be used for the generation of calcium derivatized polymers. These polymers can be functionalized with a wide variety of electrophiles, including chiral substrates, leading to novel chromatographic materials for the separation of enantiomers. The organozinc, organocopper, and 1,3-butadiene magnesium complexes have considerable potential in the synthesis of a wide range of drugs, drug delivery systems, agrochemicals, novel membranes, and polymers, including highly conducting polymers.

* information listed above is at the time of submission.

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