Ultrapure, Low Acidity Silica Microspheroid Separations

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$739,660.00
Award Year:
1996
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
22274
Agency Tracking Number:
22274
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
538 First State Boulevard, Newport, DE, 19804
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Joseph J. Kirkland
(302) 633-5889
Business Contact:
() -
Research Institute:
n/a
Abstract
Ultra-high-purity silica microspheres recently were introduced primarily for analytical high-performance liquid chromatography (HPLC). However, these materials are expensive and are available only in limited configurations. The aim is to explore new methods for preparing strong, ultra-high-purity silica microspheres (or microspheroids) of lower cost in a variety of configurations (particle size, pore size, etc.) for various separation processes. The availability of these ultra-pure, less-acidic silica particles would permit superior separations of sensitive materials, particularly those of biological origins. Such particles also would produce higher separation yields with fewer problems than are associated with currently-available silicas. Porous silica microspheroids in the 2-20 mu m range are useful for analytical HPLC separations. Similar 10-50 mu m particles are well suited for preparative HPLC and as support media for high-performance solid-phase extraction and affinity chromatography. Methods also will be sought to prepare superficially porous microspheres to permit very fast separations of macromolecules with conventional HPLC apparatus, techniques and column-packing methods. The purpose of Phase I is to develop practical preparation methods to permit ultimate commercialization of the porous silica particles of this project.

* information listed above is at the time of submission.

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