Continuous Cardiac Output Determination

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 HL52396-1,
Agency Tracking Number: 25162
Amount: $74,990.00
Phase: Phase I
Program: SBIR
Awards Year: 1994
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
2715 East 3300 South, Salt Lake City, UT, 84109
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Jeffrey Orth
 (801) 466-6465
Business Contact
Phone: () -
Research Institution
Thermal dilution, the most common method used for determining cardiac output, is highlytechnique dependant and yields results that may be off as much as +/- 2O%. To reduce error, theprocedure is often repeated a number of times and the average of all of the readings taken. Each readingrequires a bolus injection of solution, increasing the risk of sepsis and fluid overload. Modifications tothis technique using intravascular heating elements as the thermal indicator offer nearly continuousreadings but no better accuracy. A continuous cardiac output catheter will use the arterial pressure tocalculate cardiac output. The significant difference to the approach described is a method by which thesystem may be calibrated without injection of any sort of indicator. As a result, the calibration may berepeated as often as desired with no adverse effect to the patient. The phase I studies are designed toconclusively demonstrate the feasibility of the calibration method first using a mock circulation and thana number of animal experiments to validate the data. Phase II would be directed towards productdevelopment and FDA clearance for the device.

* Information listed above is at the time of submission. *

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