Rapid Assessment of Individual Soldier Operational Readiness

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$750,000.00
Award Year:
2007
Program:
STTR
Phase:
Phase II
Contract:
W911SR-07-C-0013
Agency Tracking Number:
A045-018-0156
Solicitation Year:
2006
Solicitation Topic Code:
A04-T018
Solicitation Number:
n/a
Small Business Information
RULES-BASED MEDICINE
3300 Duval Rd, Austin, TX, 78759
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
James Mapes
(512) 835-8026
jmapes@rulesbasedmedicine.com
Business Contact:
James Mapes
Chief Scientific Officer, VP R&D
(512) 835-8026
jmapes@rulesbasedmedicine.com
Research Institution:
LAWRENCE LIVERMORE NATIONAL LABORAT
Kenneth W Turteltaub
7000 East Ave.
Livermore, CA, 94550
(925) 423-8152
Federally funded R&D center (FFRDC)
Abstract
Deployed troops experience a wide variety of performance-degrading stressors, including fatigue, depressed nutrition, sustained physical activity, fear, vaccinations, environmental chemicals, and unusual pathogens. The goal of this program is to develop a hierarchical series of molecular biomarkers for the rapid assessment of a soldier's physiological and operational readiness. During Phase I, Rules-Based Medicine (RBM) and Lawrence Livermore National Laboratory (LLNL) employed a fluorescence-based microsphere array to perform Multi-Analyte Profiles (MAPs) on individuals before and after a marathon. This approach identified gender-specific biomarker patterns that deviated from an individual's physiological baseline as a response to acute physical stress. The approach also identified a subset of these biomarkers potentially useful for assessing an individual's recovery from the stress. During Phase II, we propose to identify biomarker patterns relative to stressors experienced during military activity. The rate, level and patterns of response to chronic physical stress, to added events of high, acute physical stress, and to added stressors such as heat and dehydration will be studied. It is expected that the physiological criteria obtained from the study may be used to predict performance and recovery in the field. Stress profiles may also be applied to law enforcement personnel, firefighters, athletes and may, in the future, facilitate comparison between stress responses and disease mechanisms.

* information listed above is at the time of submission.

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