The use of proteomics for surrogate markers of prion infection

Award Information
Agency:
Department of Defense
Branch
Office of the Secretary of Defense
Amount:
$99,991.00
Award Year:
2005
Program:
SBIR
Phase:
Phase I
Contract:
W81XWH-06-C-0075
Award Id:
76593
Agency Tracking Number:
O052-H06-3030
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
1008 32nd Ave, Brookings, SD, 57006
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
939726592
Principal Investigator:
Christopher Mateo
Operations Manager
(605) 692-6953
cmateo@ruraltechinc.com
Business Contact:
Christopher Chase
President
(605) 692-6953
rtilab@brookings.net
Research Institution:
n/a
Abstract
Prion diseases are unique, in that their exceptionally long incubation period makes it difficult to diagnose prior to end-stage disease. While many diagnostic assays for infectious diseases rely upon detection of specific immunity, prion diseases apparently provoke no detectable immune response. Alternative tests must therefore be developed based upon concomitant changes in gene expression associated with disease progression. While a majority of pathogolical symptoms arise in the CNS, peripheral lymphoid tissues are an alternate site of prion proliferation. These peripehral lymphoid organs would be preferable sites for the analysis of protein expression differences associated with prion disease. The Canadian National Microbiology Laboratories have recently invested in a proteomics facility for the express purpose of analyzing transmissible spongiform encephalopathies. We have partnered with this facility, due to it's unique expertise and proximity to our facility in Brookings, South Dakota. Furthermore, we have arranged to acquire pathological blood and lymph samples from scrapie-infected sheep currently housed at South Dakota State University. Our researchers will then collect and analyze data obtained from these partnerships in order to target specific changes in protein expression associated with prion diseases.

* information listed above is at the time of submission.

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