The use of proteomics for surrogate markers of prion infection

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-06-C-0075
Agency Tracking Number: O052-H06-3030
Amount: $99,991.00
Phase: Phase I
Program: SBIR
Awards Year: 2005
Solicitation Year: 2005
Solicitation Topic Code: OSD05-H06
Solicitation Number: 2005.2
Small Business Information
1008 32nd Ave, Brookings, SD, 57006
DUNS: 939726592
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Christopher Mateo
 Operations Manager
 (605) 692-6953
Business Contact
 Christopher Chase
Title: President
Phone: (605) 692-6953
Research Institution
Prion diseases are unique, in that their exceptionally long incubation period makes it difficult to diagnose prior to end-stage disease. While many diagnostic assays for infectious diseases rely upon detection of specific immunity, prion diseases apparently provoke no detectable immune response. Alternative tests must therefore be developed based upon concomitant changes in gene expression associated with disease progression. While a majority of pathogolical symptoms arise in the CNS, peripheral lymphoid tissues are an alternate site of prion proliferation. These peripehral lymphoid organs would be preferable sites for the analysis of protein expression differences associated with prion disease. The Canadian National Microbiology Laboratories have recently invested in a proteomics facility for the express purpose of analyzing transmissible spongiform encephalopathies. We have partnered with this facility, due to it's unique expertise and proximity to our facility in Brookings, South Dakota. Furthermore, we have arranged to acquire pathological blood and lymph samples from scrapie-infected sheep currently housed at South Dakota State University. Our researchers will then collect and analyze data obtained from these partnerships in order to target specific changes in protein expression associated with prion diseases.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government