Holmium Laser for Reversal of Cerebral Artery Vasospasm

Cerebral artery vasospasm may occur in patients suffering from subarachnoid hemorrhage and can resuneurological damage. The number of patients suffering from cerebral vasospasm is in excess of 20,000often produces permanently crippling effects or death in the 30-40 year old age group that exhibitspresent, there is no FDA approved procedure that is capable of permanently dilating the cerebral artbased treatment developed at Massachusetts General Hospital has been shown to reverse cerebral artercanine model. The goal of this Phase I effort will be to measure vasodilation as a function of laserex-vivo, living dog cerebral arteries in spasm. In Phase II, clinical testing would be started in orfavorable results observed in the canine model apply to humans. The long-term goal of the project woFDA approved laser system with fiber-optic delivery that would prevent the crippling effects of this