KA DUAL ENERGY X-RAY SOURCE FOR CORONARY ANGIOGRAPHY

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$458,833.00
Award Year:
1990
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
11332
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Science Research Laboratory
15 Ward St, Somerville, MA, 02143
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
A CHARACTERISTIC-LINE X-RAY SOURCE IS PROPOSED FOR DUAL-ENERGY SUBTRACTION IMAGING OF HUMAN CORONARY ARTERIES. THE SOURCE IS BASED ON THE PRODUCTION OF THE K ALPHA LINES IN A ROTATING METAL COMPOUND TARGET BOMBARDED BY A HIGH-ENERGY ELECTRON BEAM. THE ELECTRON BEAM IS PRODUCED IN AN INEXPENSIVE, COMPACT, SINGLE-RESONATOR RF ACCELERATOR. PREDICTED AVAILABLE X-RAY FLUENCES ARE COMPATIBLE WITH IMAGING OF THE CORONARY ARTERIES AFTER AN INTRAVENOUS INJECTION OF IODINE CONTRAST AGENT. THUS, THIS TECHNIQUE HAS THE POTENTIAL FOR GREATLY REDUCING PATIENT RISKS IN DIAGNOSTIC AND FOLLOWUP ANGIOGRAPHY PROCEDURES. PHASE I WILL COMPRISE AN INVESTIGATION OF K X-RAY YIELDS AND SPECTRAL PURITY OF THE RADIATION PRODUCED FROM A TARGET BOMBARDED BY A LOW-CURRENT, HIGH-ENERGY E-BEAM, AND COMPUTER CALCULATIONS OF SIGNAL-TO-NOISE RATIO IN THE SUBTRACTION IMAGE FOR OPTIMIZATION OF X-RAY SPECTRAL CHARACTERISTICS. THE STUDY WILL CULMINATE IN THE CONCEPTUALDESIGN OF A K ALPHA X-RAY SOURCE SUITABLE FOR CLINICAL USE.

* information listed above is at the time of submission.

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