IN-VIVO RESONANT-GAMMA DETECTION/IMAGING OF N AND CA

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$499,820.00
Award Year:
1992
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
16533
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Science Research Laboratory
15 Ward Street, Somerville, MA, 02143
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Flusberg, Allen M
Principal Investigator
(617) 547-1122
Business Contact:
1 R43 DK43556-01
() -
Research Institution:
n/a
Abstract
RESONANT GAMMA ABSORPTION WILL BE USED FOR IN-VIVO DETECTION AND IMAGING OF BODY NITROGEN AND CALCIUM. TWO MAJOR APPLICATIONS ARE NUTRITIONAL ASSESSMENT OF CRITICALLY ILL PATIENTS AND OSTEOPOROSIS SCREENING. REQUIRED RADIATION DOSES FOR WHOLE- BODY MEASUREMENTS ARE 3-4 ORDERS OF MAGNITUDE LOWER THAN MAY BE DONE BY PRESENT TECHNIQUES. A NOVEL, COMPACT ELECTROSTATIC PROTON ACCELERATOR WILL PRODUCE A 1 MA PROTON BEAM OF ENERGY 1.75 MEV (FOR NITROGEN DETECTION) OR 2.04 MEV (FOR CA DETECTION). PROTONS CAPTURED IN A TARGET PRODUCE GAMMA RAYS RESONANT WITH EITHER N OR CA. THE MEASURED TRANSMISSION OF THE RESONANT GAMMAS THROUGH THE BODY IS USED TO DETERMINE THE BODY CONTENT OF THESE ELEMENTS. THE TECHNIQUE REQUIRES NO RADIOACTIVE SOURCE AND A DOSE SO MODEST THAT BODY SCANS WITH 2 CM RESOLUTION ARE ENVISIONED. PHASE I IS A THEORETICAL EFFORT TO QUANTIFY THE TECHNIQUE, DESIGN AN ELECTROSTATIC ACCELERATOR, AND OPTIMIZE THE GEOMETRIC INTERFACING BETWEEN THE ACCELERATOR, TARGET AND DETECTOR SYSTEM.

* information listed above is at the time of submission.

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