IN-VIVO RESONANT-GAMMA DETECTION/IMAGING OF N AND CA

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 16533
Amount: $499,820.00
Phase: Phase II
Program: SBIR
Awards Year: 1992
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Science Research Laboratory
15 Ward Street, Somerville, MA, 02143
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Flusberg, Allen M
 Principal Investigator
 (617) 547-1122
Business Contact
 1 R43 DK43556-01
Phone: () -
Research Institution
N/A
Abstract
RESONANT GAMMA ABSORPTION WILL BE USED FOR IN-VIVO DETECTION AND IMAGING OF BODY NITROGEN AND CALCIUM. TWO MAJOR APPLICATIONS ARE NUTRITIONAL ASSESSMENT OF CRITICALLY ILL PATIENTS AND OSTEOPOROSIS SCREENING. REQUIRED RADIATION DOSES FOR WHOLE- BODY MEASUREMENTS ARE 3-4 ORDERS OF MAGNITUDE LOWER THAN MAY BE DONE BY PRESENT TECHNIQUES. A NOVEL, COMPACT ELECTROSTATIC PROTON ACCELERATOR WILL PRODUCE A 1 MA PROTON BEAM OF ENERGY 1.75 MEV (FOR NITROGEN DETECTION) OR 2.04 MEV (FOR CA DETECTION). PROTONS CAPTURED IN A TARGET PRODUCE GAMMA RAYS RESONANT WITH EITHER N OR CA. THE MEASURED TRANSMISSION OF THE RESONANT GAMMAS THROUGH THE BODY IS USED TO DETERMINE THE BODY CONTENT OF THESE ELEMENTS. THE TECHNIQUE REQUIRES NO RADIOACTIVE SOURCE AND A DOSE SO MODEST THAT BODY SCANS WITH 2 CM RESOLUTION ARE ENVISIONED. PHASE I IS A THEORETICAL EFFORT TO QUANTIFY THE TECHNIQUE, DESIGN AN ELECTROSTATIC ACCELERATOR, AND OPTIMIZE THE GEOMETRIC INTERFACING BETWEEN THE ACCELERATOR, TARGET AND DETECTOR SYSTEM.

* information listed above is at the time of submission.

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