AN ULTRA-COMPACT N-13 AMMONIA GENERATOR FOR PET

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$599,608.00
Award Year:
1994
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
19344
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Science Research Laboratory
15 Ward Street, Somerville, MA, 02143
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Rita E Shefer
(617) 547-1122
Business Contact:
() -
Research Institution:
n/a
Abstract
THE OBJECTIVE OF THIS PROGRAM IS TO DEVELOP A DEDICATED, ACCELERATOR-BASED (13)N-AMMONIA DELIVERY SYSTEM FOR POSITRON EMISSION TOMOGRAPHY (PET). (13)N-AMMONIA PET SCANS CAN ACCURATELY MEASURE MYOCARDIAL BLOOD FLOW AND HAVE BEEN SHOWN TO BE VALUABLE TOOLS IN DIAGNOSING CORONARY ARTERY DISEASE. (13)N-AMMONIA CAN ALSO BE UTILIZED TO MEASURE BLOOD FLOW IN OTHER PARTS OF THE BODY, INCLUDING THE LIVER, KIDNEY, BRAIN AND MALIGNANT TUMORS. THE GENERATOR WILL UTILIZE A VERY LOW ENERGY COAXIAL CASCADE ACCELERATOR (CCA) DEVELOPED AT SRL TO PRODUCE (13)N VIA THE (12)C(D,N)(13)N NUCLEAR REACTION. THE FULLY SHIELDED ACCELERATORY AND (13)N-AMMONIA PRODUCTION SYSTEM WILL BE HOUSED IN A 1.8 M X 1 M X 1.2 M ENCLOSURE AND WILL BE FULLY AUTOMATED WITH EASILY OPERATED PUSH-BOTTON CONTROLS. THE ESTIMATED COST OF THE (13)N-AMMONIA DELIVERY SYSTEM IS COMPARABLE TO THAT OF A ONE OF A ONE YEAR SUPPLY OF (82)RB, ANOTHER COMMONLY USED BLOOD FLOW AGENT.

* information listed above is at the time of submission.

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