Automated, Remote Production and Delivery of 15/O Radio

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$49,998.00
Award Year:
1993
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
22458
Agency Tracking Number:
22458
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Science Research Laboratory (Currently SCIENCE RESEARCH LABORATORY INC)
15 Ward Street, Somerville, MA, 02143
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Ruth E. Shefer
(617) 547-1122
Business Contact:
() -
Research Institution:
n/a
Abstract
Positron emission tomography (PET) with oxygen-15-labeled radiopharmaceuticals is becoming increasingly important in the study of mental illness. The synthesis and delivery of 15O-labeled compounds poses a unique challenged due to the extremely short half-life of this isotope and the requirement for multiple sequential doses in many procedures. This project will address the need for safe, convenient automated 15O-labeled radiopharmaceutical synthesis and patient administration. In Phase I, the key system components and automation required for production of 15O-labeled O2, CO, H2O, and butanol will be developed. Three innovative technologies will make possible a higher degree of system compactness and automation than previously achieved: an efficient, rapidly heated charcoal furnace, an in-line positron-sensitive radioactivity monitor, and a sensor for monitoring filter integrity in the final dose filtration step. The system will be housed in a self-shielded bedside unit and will allow automated, unassisted patient infusion of the liquid radiochemicals, thus, greatly reducing radiation dose to administering personnel. A simple user interface which can be controlled by the PET scanner operator will allow optimal scheduling of dose production and delivery. Phase I will culminate in the design of a system to be fabricated and tested in Phase II.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government