Automated, Remote Production and Delivery of 15/O Radio

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$49,998.00
Award Year:
1993
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
22458
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Science Research Laboratory
15 Ward Street, Somerville, MA, 02143
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Ruth E. Shefer
(617) 547-1122
Business Contact:
() -
Research Institution:
n/a
Abstract
Positron emission tomography (PET) with oxygen-15-labeled radiopharmaceuticals is becoming increasingly important in the study of mental illness. The synthesis and delivery of 15O-labeled compounds poses a unique challenged due to the extremely short half-life of this isotope and the requirement for multiple sequential doses in many procedures. This project will address the need for safe, convenient automated 15O-labeled radiopharmaceutical synthesis and patient administration. In Phase I, the key system components and automation required for production of 15O-labeled O2, CO, H2O, and butanol will be developed. Three innovative technologies will make possible a higher degree of system compactness and automation than previously achieved: an efficient, rapidly heated charcoal furnace, an in-line positron-sensitive radioactivity monitor, and a sensor for monitoring filter integrity in the final dose filtration step. The system will be housed in a self-shielded bedside unit and will allow automated, unassisted patient infusion of the liquid radiochemicals, thus, greatly reducing radiation dose to administering personnel. A simple user interface which can be controlled by the PET scanner operator will allow optimal scheduling of dose production and delivery. Phase I will culminate in the design of a system to be fabricated and tested in Phase II.

* information listed above is at the time of submission.

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