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PRODUCTION OF CARBON-11-LABELED COMPOUNDS FOR POSITRON EMISSION TOMOGRAPHY WITH A LOW ENERGY ACCELERATOR

Award Information
Agency: Department of Energy
Branch: N/A
Contract: N/A
Agency Tracking Number: 27261
Amount: $74,981.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1994
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
15 Ward St
Somerville, MA 02143
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Dr Ruth E Shefer
 (617) 547-1122
Business Contact
Phone: () -
Research Institution
N/A
Abstract

A NEW GENERATION OF ECONOMICAL, COMPACT LOW ENERGY ACCELERATORS HAVE RECENTLY BECOME AVAILABLE FOR THE PRODUCTION OF RADIOISTOTOPES FOR POSITRON EMISSION TOMOGRAPHY (PET). THIS PROJECT ADDRESSES THE NEED FOR A CARBON-11 ((11)C) PRODUCTION TARGET AND RADIOCHEMICAL SYNTHESIS SYSTEM FOR USE WITH THESE NEW ACCELERATORS. (11)C-LABELED BIOLOGICAL MOLECULES ARE USED IN A WIDE VARIETY OF IMPORTANT PET APPLICATIONS, INCLUDING THE STUDY OF RECEPTOR-BASED SYSTEMS IN THE BRAIN AND HEART, OXIDATIVE METABOLISM IN TISSUE, AND GLUCOSE METABOLISM. (11)C TARGETS CURRENTLY USED WITH PET CYCLOTRONS ARE NOT SUITABLE FOR USE AT LOW BOMBARDING ENERGY. IN PHASE I, A NEW TECHNIQUE FOR THE PRODUCTION OF (11)C IN A SOLID TARGET VIA THE (11)B(P,N)(11)C NUCLEAR REACTION WILL BE INVESTIGATED. THE GOAL OF PHASE I WILL BE TO DEVELOP AN AUTOMATED TARGET DESIGN THAT PROVIDES (11)CO2 IN CLINICALLY USEFUL QUANTITIES, WITH HIGH RADIOCHEMICAL PURITY, AND WITH SUFFICIENTLY HIGH SPECIFIC ACTIVITY FOR THE LABELING OF RECEPTOR LIGANDS AS WELL AS ACETATE AND GLUCOSE. IN PHASE II, WE WILL COUPLE THIS TARGET TO AUTOMATED RADIOCHEMISTRY SYSTEMS FOR CONVERSION OF THE EXTRACTED ACTIVITY TO (11)C-RADIOPHARMACEUTICALS COMMONLY USED IN RESEARCH AND CLINICAL PET STUDIES.

* Information listed above is at the time of submission. *

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