Development of a Novel Virus Capture System Using Positively Charged Silica Matrix

Award Information
Agency: Environmental Protection Agency
Branch: N/A
Contract: EP-D-06-086
Agency Tracking Number: EP-D-05-037
Amount: $343,486.00
Phase: Phase II
Program: SBIR
Awards Year: 2006
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
12441 Beckley St., Granger, IN, 46530
DUNS: 148374627
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Fu-Chih Hsu
 Director of Operations
 (574) 277-4078
Business Contact
 Rebecca Larkin
Title: Accounts Manager
Phone: (574) 277-4078
Research Institution
The Phase II goals aim to build upon the successful feasibility study completed during Phase I study and to complete the research required to commercialize the functionalized silica beads for virus detection and point-of use treatment applications. The primary Phase II objectives are aimed at developing two products: (1) a virus `capture-and-release¿ bead for use in human enteric virus and coliphage monitoring, and (2) a `capture-only¿ bead for point-of-use treatment applications. The study will focus on assessing the compatibility of eluates generated using the `capture-and-release¿ bead with downstream enumerative assays (both culture-based and molecular-based assays will be evaluated using water seeded with human enteric viruses), validation of the `capture-only¿ bead for point-of-use water treatment, and optimization of methods for commercial scale bead production (>1 kg functionalized beads per batch). Two silica formulations will be produced and validated for virus concentration and point-of-use treatment applications. The functionalized silica beads that will be synthesized during Phase II study have several commercial applications as low-cost human enteric virus and viral indications (coliphage) concentrations/detection products, and for incorporation into personal water purification devices.

* Information listed above is at the time of submission. *

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