Development of a Novel Virus Capture System Using Positively Charged Silica Matrix

Award Information
Agency:
Environmental Protection Agency
Branch
n/a
Amount:
$343,486.00
Award Year:
2006
Program:
SBIR
Phase:
Phase II
Contract:
EP-D-06-086
Agency Tracking Number:
EP-D-05-037
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Scientific Methods, Inc.
12441 Beckley St., Granger, IN, 46530
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
148374627
Principal Investigator:
Fu-Chih Hsu
Director of Operations
(574) 277-4078
fuchih@scientificmethods.com
Business Contact:
Rebecca Larkin
Accounts Manager
(574) 277-4078
ruby@scientificmethods.com
Research Institution:
n/a
Abstract
The Phase II goals aim to build upon the successful feasibility study completed during Phase I study and to complete the research required to commercialize the functionalized silica beads for virus detection and point-of use treatment applications. The primary Phase II objectives are aimed at developing two products: (1) a virus `capture-and-release¿ bead for use in human enteric virus and coliphage monitoring, and (2) a `capture-only¿ bead for point-of-use treatment applications. The study will focus on assessing the compatibility of eluates generated using the `capture-and-release¿ bead with downstream enumerative assays (both culture-based and molecular-based assays will be evaluated using water seeded with human enteric viruses), validation of the `capture-only¿ bead for point-of-use water treatment, and optimization of methods for commercial scale bead production (>1 kg functionalized beads per batch). Two silica formulations will be produced and validated for virus concentration and point-of-use treatment applications. The functionalized silica beads that will be synthesized during Phase II study have several commercial applications as low-cost human enteric virus and viral indications (coliphage) concentrations/detection products, and for incorporation into personal water purification devices.

* information listed above is at the time of submission.

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