TUNABLE TIME-RESOLVED FLUORESCENCE MICROSCOPY

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$49,947.00
Award Year:
1991
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
14402
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Scientific Research Associates
50 Nye Rd, Po Box 1058, Glastonbury, CT, 06033
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Dr. Salvador M. Fernandez
Director Of Applied Optics
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
DEVELOPMENT OF A TIME-RESOLVED FLUORESCENCE MICROSCOPY SYSTEM IS PROPOSED. THE SYSTEM WOULD EMPLOY ACOUSTOOPTIC TUNABLE FILTERS AS SPECTRAL TUNING ELEMENTS IN LIEU OF THE CONVENTIONAL INTERFERENCE FILTERS, AND A PHASE-MODULATED IMAGE DISSECTOR TUBE (OR A NANOSECOND GATED CCD) AS A DETECTOR. THE COMBINATION OF THESE TECHNOLOGIES IS EXPECTED TO RESULT IN A DRAMATIC IMPROVEMENT IN SENSITIVITY,VERSATILITY AND ANALYSIS SPEED. THE ABILITY TO PERFORM FLUORESCENCE LIFETIME MEASUREMENTS IN TWO DIMENSIONS SHOULD ENABLE MICROSCOPISTS TO QUANTITATE QUENCHING CORRECTIONS WHICH ARE NECESSARY TO RELATE MEASURED SIGNALS TO FLUOROPHORE CONCENTRATION.

* information listed above is at the time of submission.

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