MICROORGANISMS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
4820
Agency Tracking Number:
4820
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
791 Alexander Road, Princeton, NJ, 08540
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
PETER J MCCARTHY
PRINCIPAL INVESTIGATOR
(609) 452-7140
Business Contact:
() -
Research Institute:
n/a
Abstract
MARINE MICROORGANISMS ARE A PROMISING YET UNDERUTILIZED SOURCE OF NEW ANTITUMOR AGENTS. SEAPHARM PROPOSES TO CULTURE 360 DIVERSE MARINE MICROORGANISMS DURING THIS PHASE I PROJECT. MICROORGANISMS WILL BE EVENLY DISTRIBUTED BETWEEN NEW ISOLATES AND STRAINS FROM CULTURE COLLECTIONS AND WILL REPRESENT A WIDE VARIETY OF BACTERIAL, FUNGAL, ACTINOMYCETE, AND BLUE-GREEN ALGAL GENERA. MICROORGANISMS WILL BE ISOLATED FROM HABITATS ACCESSIBLE BY DIVERS AND DEEPSUBMERSIBLES. CULTURE OF SYMBIONTS OF HIGHER MARINE ORGANISMS WILL BE PARTICULARLY EMPHASIZED. CULTURES WILL BEGROWN IN 1- TO 2-LITER VOLUME TO YIELD 1 TO 2 GRAMS DRY CELLMASS. CELLS AND GROWTH MEDIUM WILL BE EXTRACTED, AND EXTRACTS TESTED FOR IN VITRO ANTITUMOR ACTIVITY. THE CULTURES THAT YIELD ANTITUMOR ACTIVITIES WILL BE TAXONOMI- CALLY IDENTIFIED, OPTIMAL CONDITIONS FOR PRODUCTION DETER- MINED, AND SUFFICIENT MATERIAL PREPARED TO ALLOW CHEMICAL PURIFICATION AND STRUCTURE DETERMINATION OF THE ACTIVE COMPOUND(S). ANTITUMOR ACTIVITY IS EXPECTED TO BE FOUND IN 30 TO 40 CULTURES, YIELDING 3 TO 4 LEAD COMPOUNDS. THIS PHASE I PROJECT WILL GIVE A BASE OF KNOWLEDGE ON MICRO- ORGANISMAL SOURCES OF ANTITUMOR COMPOUNDS AND A NUMBER OF LEADS TO BE DEVELOPED DURING A PHASE II CONTRACT.

* information listed above is at the time of submission.

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