MICROORGANISMS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4820
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1986
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Seapharm Inc
791 Alexander Road, Princeton, NJ, 08540
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 PETER J MCCARTHY
 PRINCIPAL INVESTIGATOR
 (609) 452-7140
Business Contact
Phone: () -
Research Institution
N/A
Abstract
MARINE MICROORGANISMS ARE A PROMISING YET UNDERUTILIZED SOURCE OF NEW ANTITUMOR AGENTS. SEAPHARM PROPOSES TO CULTURE 360 DIVERSE MARINE MICROORGANISMS DURING THIS PHASE I PROJECT. MICROORGANISMS WILL BE EVENLY DISTRIBUTED BETWEEN NEW ISOLATES AND STRAINS FROM CULTURE COLLECTIONS AND WILL REPRESENT A WIDE VARIETY OF BACTERIAL, FUNGAL, ACTINOMYCETE, AND BLUE-GREEN ALGAL GENERA. MICROORGANISMS WILL BE ISOLATED FROM HABITATS ACCESSIBLE BY DIVERS AND DEEPSUBMERSIBLES. CULTURE OF SYMBIONTS OF HIGHER MARINE ORGANISMS WILL BE PARTICULARLY EMPHASIZED. CULTURES WILL BEGROWN IN 1- TO 2-LITER VOLUME TO YIELD 1 TO 2 GRAMS DRY CELLMASS. CELLS AND GROWTH MEDIUM WILL BE EXTRACTED, AND EXTRACTS TESTED FOR IN VITRO ANTITUMOR ACTIVITY. THE CULTURES THAT YIELD ANTITUMOR ACTIVITIES WILL BE TAXONOMI- CALLY IDENTIFIED, OPTIMAL CONDITIONS FOR PRODUCTION DETER- MINED, AND SUFFICIENT MATERIAL PREPARED TO ALLOW CHEMICAL PURIFICATION AND STRUCTURE DETERMINATION OF THE ACTIVE COMPOUND(S). ANTITUMOR ACTIVITY IS EXPECTED TO BE FOUND IN 30 TO 40 CULTURES, YIELDING 3 TO 4 LEAD COMPOUNDS. THIS PHASE I PROJECT WILL GIVE A BASE OF KNOWLEDGE ON MICRO- ORGANISMAL SOURCES OF ANTITUMOR COMPOUNDS AND A NUMBER OF LEADS TO BE DEVELOPED DURING A PHASE II CONTRACT.

* information listed above is at the time of submission.

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