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Low Voltage, Economical Electroporation Device

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43GM085829-01
Agency Tracking Number: GM085829
Amount: $105,132.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: PHS2007-2
Solicitation Year: 2008
Award Year: 2008
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
LA JOLLA, CA 92037
United States
DUNS: 969813278
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 () -
Business Contact
Phone: (858) 638-0315
Research Institution

DESCRIPTION (provided by applicant): Electroporation describes the process of exposing cells to high electrical field which leads to transient membrane permeabilization. This procedure has gained widespread use in the life sciences for intracellular delive
ry of nucleic acids, ions, dyes and drugs. Current electroporation techniques require specialized power supplies to create the high electrical field strengths necessary for successful delivery applications. We propose the development of an alternate new el
ectroporation device stimulated by recent work describing electroporation of cells flowing through microfluidic channels. Our device will also permit the use of low voltages, but enable high volume sample processing, function with standard power supplies,
and be applicable for prokaryotic and eukaryotic cells. The research proposed will define alternative uses for the system including high throughput reagentless cell lysis and electrical field pasteurization. The products developed during this research will
enable widespread use of electroporation at significantly reduced costs. PUBLIC HUMAN RELEVANCE: The proposed research will lead to the development of novel electroporation devices that can be used by the biomedical research community to enhance the basic
understanding of disease processes. This product will have a direct impact on public health by enabling a novel, low heat and energy use process for pasteurization.

* Information listed above is at the time of submission. *

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