EVALUATION OF A MICROENCAPSULATED PARAINFLUENZA VACCINE

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 13646
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1990
Solitcitation Year: N/A
Solitcitation Topic Code: N/A
Solitcitation Number: N/A
Small Business Information
Secretech Inc
1025 18th St S #201, Birmingham, AL, 35294
Duns: N/A
Hubzone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Miroslav Novak
 (205) 930-9384
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO DEVELOP A COMMERCIAL TRIVALENT GLYCOPROTEIN SUBUNIT VACCINE FOR PARAINFLUENZA VIRUSES. BECAUSE OF THE HIGH COST OF PREPARING THESE GLYCOPROTEINS, A MEANS FOR ACHIEVING AN ENHANCED IMMUNE RESPONSE IS AN IMPORTANT OBJECTIVE AND IS THE FOCUS OF THIS RESEARCH. BIOCOMPATIBLE AND BIODEGRADABLE MICROSPHERES CONSISTING OF ACOPOLYMER OF DL-LACTIDE AND GLYCOLIDE (POLY DL-LACTIDE-CO-GLYCOLIDE) WILL BE UTILIZED TO INCORPORATE INACTIVATED HUMAN PARAINFLUENZA TYPE 3 (PI3) VIRUS ANTIGENS INTO SMALL SPHERICAL PARTICLES (1-10 MU M). MICROSPHERES CONTAINING VIRAL ANTIGENS WILL BE USED FOR SUBCUTANEOUS, INTRANASAL, AND ORAL IMMUNIZATION OF EXPERIMENTAL ANIMALS, AND THEIR IMMUNE RESPONSE WILL BE EVALUATED. A DIFFERENT GROUP OF ANIMALS WILL BE SIMILARLY IMMUNIZED WITH INACTIVATED VIRUS IN SOLUTION FOR COMPARISON. IF A SIGNIFICANT ENHANCEMENT IN THE PROTECTIVE IMMUNE RESPONSE IS OBSERVED USING MICROENCAPSULATED PI3 VIRUS ANTIGENS, MORE DETAILED STUDIES WILL BE SUBSEQUENTLY PURSUED FOR DEVELOPMENT OF A MULTIVALENT SUBUNIT VACCINE USING PARAINFLUENZA TYPE 1, 2, AND 3 ENVELOPE GLYCOPROTEINS. STUDIES WILL ALSO BE CONDUCTED TO UNDERSTANDTHE MECHANISM OF PROTECTION AND THE DURATION OF SUCH RESPONSE. FINALLY, MICROENCAPSULATED VIRUS ENVELOPE GLYCOPROTEINS WILL BE UTILIZED FOR A CLINICAL FIELD TRIAL FOR IMMUNOPROPHYLAXIS AGAINST NATURAL INFECTION FROM PARAINFLUENZA VIRUSES.

* information listed above is at the time of submission.

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