Mucosal Immunity Against Non-infectious SIV Particles

Award Information

Agency: Department of Health and Human Services

Branch: N/A

Contract: N/A

Agency Tracking Number: 21871

Amount: $49,999.00

Phase: Phase I

Program: SBIR

Solicitation Topic Code: N/A

Solicitation Number: N/A

Timeline

Solicitation Year: N/A

Award Year: 1993

Award Start Date (Proposal Award Date): N/A

Award End Date (Contract End Date): N/A

Small Business Information

Secretech, Inc.

1025 18th Street, South

Birmingham, AL 35205

United States

DUNS: N/A

HUBZone Owned: No

Woman Owned: No

Socially and Economically Disadvantaged: No

Principal Investigator

Name: Prasanna Kumar
Phone: (205) 930-9384

Business Contact

Phone: () -

Research Institution

N/A

Abstract

The long term objective is to induce a protective mucosal immune response to prevent HIV-1 infection. We will immunize orally with recombinant defective SIV-like particles entrapped in microcapsules of lactige-glyco- lide copolymer in order to stimulate a mucosal immune response in mice. The effectiveness of the microcapsule in protecting the immunogenicity of the gag-env will be established by treating the microcapsules with stimulated gastric and intestinal juices, and the resulting protein will be characterized by immunoblot and SDS-PAGE analysis. The optimized microcapsules will be administered to mice orally in parallel with gag-env in solution. The antibody response in serum, saliva and lavages from the gut and the vagina of immunized mice will be determined. In Phase II, we will study the response of immunized macaques challenged with SIV through the vaginal route.

* Information listed above is at the time of submission. *

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Mucosal Immunity Against Non-infectious SIV Particles